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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prognostic role of aortic atherosclerosis and coronary flow reserve in patients with suspected coronary artery disease
International Journal of Cardiology, Volume 131, No. 1, Year 2008
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Description
Background: The degree of aortic atherosclerosis (AA) and coronary flow reserve (CFR) can be evaluated simultaneously during the same transoesophageal echocardiographic (TEE) examination. The aim of the present study was to assess the relative prognostic value of simultaneously evaluated CFR and AA by TEE in patients with suspected or known coronary artery disease (CAD). Methods: The present study comprised 397 inhospital patients with chest pain. All patients underwent a transthoracic echocardiographic study to evaluate left ventricular function and a vasodilator TEE study to evaluate simultaneously CFR and the degree of AA. Results: Coronary angiography was performed in 292 patients (74%). Significant CAD was less frequent in patients with normal CFR and low-grade AA. During a mean follow-up of 41 ± 12 months, 23 patients suffered cardiovascular death (14 sudden cardiac death, 7 heart failure, 2 cardiovascular thrombosis). Univariate analysis yielded age, diabetes, AA grade and CFR as predictors of survival. Multivariate regression analysis showed that only CFR (hazard ratio (HR) 2.9, P < 0.02) and diabetes (HR 3.8, P < 0.01) were independent predictors of survival. Conclusions: It can be said that both CFR and AA grade are associated with poor survival but only CFR is an independent predictor. © 2007 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Nemes, Attila
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Forster, Tamás
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Geleijnse, Marcel L.
Netherlands, Rotterdam
Erasmus Mc
Soliman, O. I.I.
Netherlands, Rotterdam
Erasmus Mc
Ten Cate, Folkert J.
Netherlands, Rotterdam
Erasmus Mc
Csanády, Miklós
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Statistics
Citations: 12
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.ijcard.2007.08.137
ISSN:
01675273
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative