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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
Nature Communications, Volume 11, No. 1, Article 736, Year 2020
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Description
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb of an SV breakpoint associates with altered expression. For the majority of these genes, expression increases rather than decreases with corresponding breakpoint events. Up-regulated cancer-associated genes impacted by this phenomenon include TERT, MDM2, CDK4, ERBB2, CD274, PDCD1LG2, and IGF2. TERT-associated breakpoints involve ~3% of cases, most frequently in liver biliary, melanoma, sarcoma, stomach, and kidney cancers. SVs associated with up-regulation of PD1 and PDL1 genes involve ~1% of non-amplified cases. For many genes, SVs are significantly associated with increased numbers or greater proximity of enhancer regulatory elements near the gene. DNA methylation near the promoter is often increased with nearby SV breakpoint, which may involve inactivation of repressor elements. © 2020, The Author(s).
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Authors & Co-Authors
Zhang, Yiqun
United States, Houston
Baylor College of Medicine
Fonseca, Nuno A.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Portugal, Porto
Universidade do Porto
Brazma, A. N.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Awadalla, Philip
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
University of Toronto
Cortes-Ciriano, Isidro
United Kingdom, Cambridge
University of Cambridge
United States, Boston
Harvard Medical School
Frenkel-Morgenstern, Milana
Israel, Ramat Gan
Bar-ilan University
Hoadley, Katherine A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Huska, Matthew R.
Germany, Berlin
Max Delbruck Center for Molecular Medicine
Kahles, André
United States, New York
Memorial Sloan-kettering Cancer Center
Switzerland, Zurich
Eth Zürich
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Zurich
Universitatsspital Zurich
Kilpinen, Helena
United Kingdom, London
University College London
Korbel, Jan O.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Lamaze, Fabien C.
Canada, Toronto
Ontario Institute for Cancer Research
Liu, Dongbing
China, Shenzhen
Bgi-shenzhen
China, Shenzhen
China National Genebank
Meyerson, Matthew L.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
Switzerland, Bern
University of Bern
Australia, Melbourne
University of Melbourne
United States, Boston
Harvard Medical School
United States, New Haven
Yale University
Ojesina, Akinyemi I.
United States, Birmingham
The University of Alabama at Birmingham
United States, Huntsville
Hudsonalpha Institute for Biotechnology
Ouellette, Bf Francis
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
University of Toronto
Pan-Hammarström, Qiang
China, Shenzhen
Bgi-shenzhen
Sweden, Stockholm
Karolinska Institutet
Pedamallu, Chandra Sekhar
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Dana-farber Cancer Institute
Rätsch, Gunnar
United States, New York
Memorial Sloan-kettering Cancer Center
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
United States, New York
Weill Cornell Medicine
Switzerland, Zurich
Universitatsspital Zurich
Switzerland, Zurich
Eth Zürich
Siebert, Reiner
Denmark, Copenhagen
Københavns Universitet
Germany, Ulm
Universität Ulm
Germany, Kiel
Christian-albrechts-universität zu Kiel
Stegle, Oliver
United Kingdom, Hinxton
European Molecular Biology Laboratory
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Germany, Heidelberg
German Cancer Research Center
Teh, Bin Tean
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Duke-nus Medical School
Singapore, Singapore City
A-star, Institute of Molecular and Cell Biology
Singapore, Singapore City
National Cancer Centre, Singapore
Urban, Lara
United Kingdom, Hinxton
European Molecular Biology Laboratory
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Waszak, Sebastian M.
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Wu, Kui
China, Shenzhen
Bgi-shenzhen
China, Shenzhen
China National Genebank
Yang, Huanming
China, Shenzhen
Bgi-shenzhen
Akdemir, Kadir Caner
United States, Houston
The University of Texas Md Anderson Cancer Center
Baez-Ortega, Adrian
United Kingdom, Cambridge
University of Cambridge
Beroukhim, Rameen
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Dana-farber Cancer Institute
Brors, Benedikt
Germany, Heidelberg
German Cancer Research Center
Campbell, Peter J.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Hinxton
Wellcome Sanger Institute
Estivill, Xavier
Qatar, Doha
Sidra Medicine
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Etemadmoghadam, Dariush
Australia, Melbourne
Peter Maccallum Cancer Centre
Gerstein, Mark B.
United States, Princeton
Princeton University
United States, New Haven
Yale University
Hutter, Barbara
Germany, Heidelberg
German Cancer Research Center
Lynch, Andy G.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, St Andrews
School of Medicine
Macintyre, Geoff
United Kingdom, Cambridge
University of Cambridge
Martincorena, Iñigo
United Kingdom, Hinxton
Wellcome Sanger Institute
Miyano, Satoru
Japan, Tokyo
The Institute of Medical Science, the University of Tokyo
Ossowski, Stephan
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Germany, Tubingen
Eberhard Karls Universität Tübingen
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Schumacher, Steven E.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
Shackleton, Mark J.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Peter Maccallum Cancer Centre
Yoon, Sung-soo
United States, New York
New York Genome Center
Zamora, Jorge
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Spain, Vigo
Universidade de Vigo
United Kingdom, Hinxton
Wellcome Sanger Institute
Creighton, Chad J.
United States, Houston
Baylor College of Medicine
United States, Houston
The University of Texas Md Anderson Cancer Center
Aaltonen, Lauri A.
Finland, Helsinki
Helsingin Yliopisto
Abascal, Federico
United Kingdom, Hinxton
Wellcome Sanger Institute
Adams, David J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Alawi, Malik
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Germany, Hamburg
Heinrich-pette-institut Leibniz-institut Für Experimentelle Virologie
Alexandrov, Ludmil B.
United Kingdom, Hinxton
Wellcome Sanger Institute
United States, La Jolla
University of California, San Diego
United States, La Jolla
Moores Cancer Center
Alsop, Kathryn
Australia, Melbourne
Peter Maccallum Cancer Centre
Amary, Fernanda M.
United Kingdom, Stanmore
Royal National Orthopaedic Hospital Nhs Trust
Ammerpohl, Ole
Germany, Kiel
Christian-albrechts-universität zu Kiel
Germany, Ulm
Universität Ulm
Armenia, Joshua
United States, New York
Memorial Sloan-kettering Cancer Center
Asa, Sylvia L.
Canada, Toronto
University Health Network University of Toronto
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Aukema, Sietse M.
Germany, Ulm
Universität Ulm
Germany, Kiel
Christian-albrechts-universität zu Kiel
Bandopadhayay, Pratiti
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Barnholtz-Sloan, Jill S.
United States, Cleveland
Case School of Medicine
United States, Cleveland
University Hospitals Case Medical Center
Barr, Hugh M.D.
United Kingdom, Gloucester
Gloucestershire Royal Hospital
Bathe, Oliver F.
Canada, Calgary
University of Calgary
Bavi, Prashant P.
Canada, Toronto
Ontario Institute for Cancer Research
Behren, Andreas
Australia, Melbourne
La Trobe University
Beltrán, Sergi
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Berchuck, Andrew
United States, Durham
Duke University Medical Center
Bergmann, Anke K.
Germany, Hannover
Hannover Medical School
Bergstrom, Erik N.
United States, La Jolla
University of California, San Diego
United States, La Jolla
Moores Cancer Center
Berney, Daniel Maurice
United Kingdom, London
Queen Mary University of London
Bernhart, Stephan H.F.
Germany, Leipzig
Universität Leipzig
Bieg, Matthias
Germany, Berlin
Charité – Universitätsmedizin Berlin
Germany, Heidelberg
German Cancer Research Center
Binder, Hans
Germany, Leipzig
Universität Leipzig
Birney, Ewan
United Kingdom, Hinxton
European Molecular Biology Laboratory
Birrer, Michael J.
United States, Boston
Massachusetts General Hospital
Biswas, Nidhan K.
India, Kalyani
National Institute of Biomedical Genomics
De Bono, Johann Sebastian
United Kingdom, London
The Institute of Cancer Research
Borg, Åke
Sweden, Lund
Lunds Universitet
Borkhardt, Arndt K.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Boroevich, Keith Anthony
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Boultwood, Jacqueline
United Kingdom, Oxford
University of Oxford
Bourque, Guillaume
Canada, Montreal
Université Mcgill
Bowen, David T.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Leeds
Leeds Teaching Hospitals Nhs Trust
Bowlby, Reanne
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Brennan, Paul J.
Switzerland, Geneva
Organisation Mondiale de la Santé
Brock, Jane E.
United States, Boston
Brigham and Women's Hospital
Broeks, Annegien
Netherlands, Amsterdam
The Netherlands Cancer Institute
Brooks, Denise B.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Buchhalter, Ivo
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universität Heidelberg
Bullman, Susan
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Dana-farber Cancer Institute
Burkhardt, Birgit
Germany, Munster
Universitätsklinikum Münster
Butler, Adam P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Borresen-Dale, Anne Lise
Norway, Oslo
Rikshospitalet-radiumhospitalet hf
Norway, Oslo
Universitetet I Oslo
Caesar-Johnson, Samantha J.
United States, Bethesda
National Institutes of Health Nih
Calvo, Fabien
France, Villejuif
Institut de Cancerologie Gustave Roussy
Campo, Elías
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Cazzola, Mario
Italy, Pavia
Università Degli Studi Di Pavia
Cebon, Jonathan Simon
Australia, Melbourne
La Trobe University
Cerfolio, Robert James
United States, Birmingham
The University of Alabama at Birmingham
Chalmers, Don R.C.
Australia, Hobart
University of Tasmania
Chan-Seng-Yue, Michelle A.
Canada, Toronto
Ontario Institute for Cancer Research
Chanock, Stephen J.
United States, Bethesda
National Institutes of Health Nih
Chantrill, Lorraine A.
Australia, Sydney
The Kinghorn Cancer Centre
Chayama, Kazuaki
Japan, Higashihiroshima
Hiroshima University
Chiew, Yoke Eng
Australia, Parramatta
The Westmead Institute for Medical Research
Australia, Sydney
Westmead Hospital
Chin, Suet Feung
United Kingdom, Cambridge
University of Cambridge
Cho, Juok
United States, Cambridge
Massachusetts Institute of Technology
Chomienne, Christine
France, Boulogne-billancourt
Institut National du Cancer
Chou, Angela S.Y.
Australia, Sydney
The Kinghorn Cancer Centre
Australia, Parramatta
The Westmead Institute for Medical Research
Cibulskis, Kristian
United States, Cambridge
Massachusetts Institute of Technology
Clapham, Peter
United Kingdom, Hinxton
Wellcome Sanger Institute
Claviez, Alexander
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Cloonan, Nicole
New Zealand, Auckland
The University of Auckland
Collins, Colin C.
Canada, Vancouver
Vancouver Prostate Centre
Cooke, Susanna L.
United Kingdom, Glasgow
University of Glasgow
Cordner, Stephen M.
Australia, Melbourne
Victorian Institute of Forensic Medicine
de la Vega, Francisco M.
United States, Stanford
Stanford University School of Medicine
United States, Palo Alto
Stanford University
DeFreitas, Timothy
United States, Cambridge
Massachusetts Institute of Technology
Delaneau, Olivier
Switzerland, Lausanne
Université de Lausanne Unil
Switzerland, Geneva
Université de Genève Faculté de Médecine
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Demchok, John A.
United States, Bethesda
National Institutes of Health Nih
Deshpande, Vikram S.
United States, Boston
Massachusetts General Hospital
Desmedt, Christine
Belgium, Brussels
Institut Jules Bordet
Belgium, Leuven
Ku Leuven
Dhir, Rajiv J.
United States, Pittsburgh
Upmc Shadyside
Dinh, Huy Q.
United States, Los Angeles
Cedars-sinai Medical Center
Dirix, Luc Yves
Belgium, Antwerpen
Universiteit Antwerpen
Doddapaneni, Harshavardhan
United States, Houston
Baylor College of Medicine
Drechsel, O.
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Dudderidge, Tim J.
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Dursi, Lewis Jonathan
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
Hospital for Sick Children University of Toronto
Duthie, Fraser R.
United Kingdom, Glasgow
University of Glasgow
United Kingdom, Glasgow
Queen Elizabeth University Hospital, Glasgow
Dutton-Regester, Ken
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Easton, Douglas F.
United Kingdom, Cambridge
University of Cambridge
Eeles, Rosalind A.
United Kingdom, London
The Institute of Cancer Research
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Escaramis, Georgia
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Eyfjörd, Jórunn Erla
Iceland, Reykjavik
Icelandic Cancer Society
Faltas, Bishoy Morris
United States, New York
Weill Cornell Medicine
Faquin, William C.
United States, Boston
Massachusetts General Hospital
Fassan, Matteo
Italy, Padua
Università Degli Studi Di Padova
Felau, Ina
United States, Bethesda
National Institutes of Health Nih
Fereday, Sian
Australia, Melbourne
Peter Maccallum Cancer Centre
Ferguson, Martin L.
United States, Bethesda
National Institutes of Health Nih
Ferretti, Vincent
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Montreal
University of Montreal
Fisher, Cyril J.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Fitzgerald, Rebecca Claire
United Kingdom, Cambridge
University of Cambridge
Flanagan, Adrienne Margaret
United Kingdom, London
University College London
Fleshner, Neil Eric
Canada, Toronto
Princess Margaret Cancer Centre
Flicek, Paul R.
United Kingdom, Hinxton
European Molecular Biology Laboratory
Fong, Kwun M.
Australia, Chermside
The Prince Charles Hospital
Frazer, Scott
United States, Cambridge
Massachusetts Institute of Technology
Fronick, Catrina C.
United States, St. Louis
Washington University in St. Louis
United Kingdom, Norwich
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Fulton, Robert S.
United States, St. Louis
Washington University in St. Louis
United States, St. Louis
Washington University School of Medicine in St. Louis
Gabriel, Stacey Bolk
United States, Cambridge
Massachusetts Institute of Technology
Gallinger, Steven J.
Canada, Toronto
Ontario Institute for Cancer Research
Canada, Toronto
University Health Network University of Toronto
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Gambacorti Passerini, Carlo B.
Italy, Milan
Università Degli Studi Di Milano-bicocca
Garraway, Levi A.
United States, Boston
Dana-farber Cancer Institute
Garrison, Erik P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Gehlenborg, Nils
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Gelpí, Josep Lluís
Spain, Barcelona
Centro Nacional de Supercomputación
Spain, Barcelona
Universitat de Barcelona
Gerhard, Daniela Se
United States, Bethesda
National Institutes of Health Nih
Gerhäuser, Clarissa
Germany, Heidelberg
German Cancer Research Center
Getz, Gad A.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Ghori, Mohammed J.R.
United Kingdom, Hinxton
Wellcome Sanger Institute
Gibbs, Richard A.
United States, Houston
Baylor College of Medicine
Gill, Anthony J.
Australia, Sydney
The Kinghorn Cancer Centre
Australia, Sydney
The University of Sydney
Gill, Pelvender Singh
United Kingdom, Oxford
University of Oxford
Giri, Dilip D.
United States, New York
Memorial Sloan-kettering Cancer Center
Gnanapragasam, Vincent J.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
United Kingdom, Cambridge
University of Cambridge
Gossage, James A.
United Kingdom, London
St Thomas' Hospital
Graham, Janet Shirley
United Kingdom, Glasgow
University of Glasgow
United Kingdom, Glasgow
Beatson West of Scotland Cancer Centre
Green, Anthony Reidunn T.
United Kingdom, Cambridge
University of Cambridge
Green, Eric D.
United States, Bethesda
National Institutes of Health Nih
Grimmond, Sean M.
Australia, Melbourne
University of Melbourne
Grossman, Robert Lee
United States, Chicago
The University of Chicago
Grundhoff, Adam T.
Germany, Hamburg
Heinrich-pette-institut Leibniz-institut Für Experimentelle Virologie
Germany, Hamburg
Partner Site Hamburg-lübeck-borstel-riems
Gut, I. Glynne
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Gut, Marta
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Göke, Jonathan
Singapore, Singapore City
A-star, Genome Institute of Singapore
Singapore, Singapore City
National Cancer Centre, Singapore
Haider, Syed Asma
Canada, Toronto
Ontario Institute for Cancer Research
Hamdy, Freddie C.
United Kingdom, Oxford
University of Oxford
Hamilton, Anne L.
Australia, Melbourne
Peter Maccallum Cancer Centre
Hanna, George Bushra
United Kingdom, London
Imperial College London
Hansmann, Martin Leo
Germany, Frankfurt am Main
Senckenberg Forschungsinstitut Und Naturmuseum
Harmanci, Arif Ozgun
United States, New Haven
Yale University
United States, Houston
University of Texas Health Science Center at Houston
Harrington, Eoghan Donal
United Kingdom, Oxford
Oxford Nanopore Technologies
Heath, Simon C.
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Hedley, David William
Canada, Toronto
Princess Margaret Cancer Centre
Hegde, Apurva M.
United States, Houston
The University of Texas Md Anderson Cancer Center
Heinold, Michael C.
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universität Heidelberg
Heisler, Lawrence E.
Canada, Toronto
Ontario Institute for Cancer Research
Helmy, Mohamed
Canada, Toronto
University of Toronto
Hobolth, Asger
Denmark, Aarhus
Aarhus Universitet
Hoell, Jessica I.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Hoffmann, Steve
Germany, Leipzig
Universität Leipzig
Germany, Jena
Leibniz Institute on Aging - Fritz Lipmann Institute
Hofmann, Oliver M.
Australia, Melbourne
University of Melbourne
Hou, Yong
China, Shenzhen
Bgi-shenzhen
China, Shenzhen
China National Genebank
Hovestadt, Volker
Germany, Heidelberg
German Cancer Research Center
Hua, Xing
United States, Bethesda
National Institutes of Health Nih
Huang, Mei
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Huber, Wolfgang K.
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Hudson, Thomas J.
Canada, Toronto
Ontario Institute for Cancer Research
United States, North Chicago
Abbvie
Hummel, Michael
Germany, Berlin
Charité – Universitätsmedizin Berlin
Hung, Jillian A.
Australia, Parramatta
The Westmead Institute for Medical Research
Australia, Sydney
Westmead Hospital
Huntsman, David G.
Canada, Vancouver
British Columbia Cancer Agency
Hupp, Ted R.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Hutter, Carolyn M.
United States, Bethesda
National Institutes of Health Nih
Hübschmann, Daniel
Germany, Heidelberg
Universität Heidelberg
Germany, Heidelberg
Universitätsklinikum Heidelberg
Germany, Heidelberg
German Cancer Research Center
Imoto, Seiya
Japan, Tokyo
The University of Tokyo
Isaacs, William B.
United States, Baltimore
Johns Hopkins Medicine
Ishikawa, Shumpei
Japan, Tokyo
The University of Tokyo
Iskar, Murat
Germany, Heidelberg
German Cancer Research Center
Ittmann, Michael M.
United States, Houston
Baylor College of Medicine
United States, Houston
Michael E. Debakey va Medical Center
Jacquemier, Jocelyne D.
South Korea, Seoul
Hanyang University
Jayaseelan, Joy Christina
United States, Houston
Baylor College of Medicine
Ji, Yuan
United States, Chicago
The University of Chicago
United States, Evanston
Northshore University Healthsystem
Johns, Amber L.
Australia, Sydney
The Kinghorn Cancer Centre
Joly, Yann
Canada, Montreal
Université Mcgill
Jonasson, J. G.
Iceland, Reykjavik
Icelandic Cancer Society
Jones, Corbin D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Jones, David R.
United Kingdom, Hinxton
Wellcome Sanger Institute
Jones, David T.W.
Germany, Heidelberg
Hopp Children's Cancer Center Heidelberg Kitz
Germany, Heidelberg
German Cancer Research Center
Von-Kalle, Christof
Germany, Heidelberg
German Cancer Research Center
Karlan, Beth Y.
United States, Los Angeles
Cedars-sinai Medical Center
Kassahn, Karin S.
Australia, Brisbane
The University of Queensland
Kebebew, Electron K.
United States, Washington, D.c.
The George Washington University
United States, Bethesda
National Institutes of Health Nih
Kellis, Manolis
United States, Cambridge
Massachusetts Institute of Technology
Kench, J. G.
Australia, Sydney
The Kinghorn Cancer Centre
Australia, Sydney
The University of Sydney
Australia, Sydney
Royal Prince Alfred Hospital
Kennedy, Catherine J.
Australia, Parramatta
The Westmead Institute for Medical Research
Australia, Sydney
Westmead Hospital
Khoo, Vincent S.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Kim, Jaegil
United States, Cambridge
Massachusetts Institute of Technology
King, Tari A.
United States, Boston
Dana-farber Cancer Institute
United States, New York
Memorial Sloan-kettering Cancer Center
United States, Boston
Brigham and Women's Hospital
Klapper, Wolfram
Germany, Kiel
Christian-albrechts-universität zu Kiel
Kleinheinz, Kortine
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universität Heidelberg
Knappskog, Stian
United Kingdom, Hinxton
Wellcome Sanger Institute
Norway, Bergen
Universitetet I Bergen
Knoppers, Bartha Maria
Canada, Montreal
Université Mcgill
Kool, Marcel
Germany, Heidelberg
Hopp Children's Cancer Center Heidelberg Kitz
Germany, Heidelberg
German Cancer Research Center
Korchina, Viktoriya
United States, Houston
Baylor College of Medicine
Korshunov, Andrey G.
Germany, Heidelberg
German Cancer Research Center
Kóte-Jarai, Zsofia S.
United Kingdom, London
The Institute of Cancer Research
Kremeyer, Barbara
United Kingdom, Hinxton
Wellcome Sanger Institute
Lagergren, Jesper H.F.
Sweden, Stockholm
Karolinska Institutet
United Kingdom, London
King's College London
Laird, Peter W.
United States, Grand Rapids
Van Andel Research Institute
Lakhani, Sunil R.
Australia, Brisbane
Royal Brisbane and Women's Hospital
Lander, Eric S.
United States, Cambridge
Massachusetts Institute of Technology
Larsimont, Denis P.
Belgium, Brussels
Institut Jules Bordet
Lathrop, Mark G.
Canada, Montreal
Université Mcgill
Lawerenz, Chris
Germany, Berlin
Charité – Universitätsmedizin Berlin
Lawlor, Rita T.
Unknown Affiliation
Lee, Ming Ta Michael
Taiwan, Nankang
Academia Sinica Taiwan
Lehmann, Kjong Van
United States, New York
Memorial Sloan-kettering Cancer Center
Switzerland, Zurich
Eth Zürich
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Zurich
Universitatsspital Zurich
Lehrach, Hans R.
Germany, Berlin
Max Planck Institute for Molecular Genetics
Lenze, Dido
Germany, Berlin
Charité – Universitätsmedizin Berlin
Leshchiner, Ignaty D.
United States, Cambridge
Massachusetts Institute of Technology
Letunić, Ivica
Unknown Affiliation
Lewis, Lora R.
United States, Houston
Baylor College of Medicine
Li, Haiyan Irene
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Lin, Pei
United States, Cambridge
Massachusetts Institute of Technology
Liu, Jia
United States, Reston
Leidos Inc.
Livingstone, Julie M.
Canada, Toronto
Ontario Institute for Cancer Research
Loeffler, Markus
Germany, Leipzig
Universität Leipzig
Long, Georgina V.
Unknown Affiliation
Louis, David N.
United States, Boston
Massachusetts General Hospital
Lovat, Laurence Bruce
United Kingdom, London
University College London
Lu, Yongjie
United Kingdom, London
Queen Mary University of London
China, Shanghai
Second Military Medical University
Luchini, Claudio
Unknown Affiliation
Lynch, Andy G.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, St Andrews
School of Medicine
López, Cristina E.
Germany, Kiel
Christian-albrechts-universität zu Kiel
Germany, Ulm
Universität Ulm
Ma, Yussanne P.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Maitra, Arindam
India, Kalyani
National Institute of Biomedical Genomics
Majumder, Partha Pratim
India, Kalyani
National Institute of Biomedical Genomics
Malcovati, Luca
Italy, Pavia
Università Degli Studi Di Pavia
Malleo, Giuseppe
Unknown Affiliation
Marchal, Kathleen
Belgium, Ghent
Universiteit Gent
Mardis, Elaine R.
United States, Portland
Oregon Health & Science University
Marques-Bonet, Tomas
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Spain, Cerdanyola Del Valles
Institut Català de Paleontologia Miquel Crusafont
Martens, J. W. M. W.M.
Netherlands, Rotterdam
Erasmus Mc
Martín-Subero, J. I.
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Matthews, Lucy H.
United Kingdom, London
The Institute of Cancer Research
Meier, Samuel R.
United States, Cambridge
Massachusetts Institute of Technology
Menzies, Andrew
United Kingdom, Hinxton
Wellcome Sanger Institute
Merrett, Neil D.
Australia, Penrith
Western Sydney University
Mileshkin, Linda Rose
Australia, Melbourne
Peter Maccallum Cancer Centre
Minner, Sarah J.P.
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Mirabello, Lisa J.
United States, Bethesda
National Institutes of Health Nih
Moore, Richard A.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Morrison, Carl D.
Australia, Melbourne
University of Melbourne
United States, Buffalo
Roswell Park Cancer Institute
Mungall, Karen L.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Mustonen, Ville
Finland, Helsinki
Helsingin Yliopisto
Muzny, Donna Marie
United States, Houston
Baylor College of Medicine
Möller, Peter Lange
Germany, Ulm
Universität Ulm
Nakagawa, Hidewaki
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Navarro, Arcadi
Spain, Barcelona
Barcelona Institute of Science and Technology Bist
Spain, Barcelona
Csic-upf - Instituto de Biologia Evolutiva Ibe
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Newton, Yulia
United States, Santa Cruz
University of California, Santa Cruz
Noble, Michael S.
United States, Cambridge
Massachusetts Institute of Technology
Northcott, Paul A.
United States, Memphis
St. Jude Children's Research Hospital
O'Donovan, Maria L.
United Kingdom, Cambridge
University of Cambridge
Ogden, Christopher W.
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Ohdan, Hideki
Japan, Higashihiroshima
Hiroshima University
Omberg, Larsson
United States, Seattle
Sage Bionetworks
Ott, German K.
Germany, Stuttgart
Robert Bosch Krankenhaus Stuttgart
Paiella, Salvatore
Unknown Affiliation
Papatheodorou, Irene
United Kingdom, Hinxton
European Molecular Biology Laboratory
Parker, Joel S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Patch, Ann Marie
Australia, Brisbane
The University of Queensland
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Pennell, Nathan A.
United States, Cleveland
Cleveland Clinic Foundation
Olson, Gloria Moy
United States, Portland
Oregon Health & Science University
Pfister, Stefan Michael
Germany, Heidelberg
Hopp Children's Cancer Center Heidelberg Kitz
Germany, Heidelberg
German Cancer Research Center
Germany, Heidelberg
Universitätsklinikum Heidelberg
Pihl, Todd D.
United States, Reston
General Dynamics Corporation
Pillay, Nischalan
United Kingdom, London
University College London
Pinder, Sarah E.
United Kingdom, London
Imperial College Academic Health Science Centre
Pivot, Xavier B.
France, Besancon
Interactions Hôte-greffon, Tumeur et Ingénierie Cellulaire et Génique
Polak, Paz P.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Popescu, Irinel
Romania, Bucharest
Institutul Clinic Fundeni
Preston, Shaun R.
United Kingdom, Guildford
Royal Surrey County Hospital
Pritchard, Antonia L.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Provenzano, Elena
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Pulido-Tamayo, Sergio
Belgium, Ghent
Universiteit Gent
Purdie, Colin A.
United Kingdom, Dundee
Ninewells Hospital
Rader, Janet S.
United States, Milwaukee
Medical College of Wisconsin
Raeder, Benjamin
Germany, Heidelberg
European Molecular Biology Laboratory Heidelberg
Ramalingam, Suresh S.
United States, Atlanta
Emory University
Reifenberger, Guido
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Reis-Filho, Jorge Sérgio
United States, New York
Memorial Sloan-kettering Cancer Center
Reynolds, Sheila M.
United States, Seattle
Institute for Systems Biology
Riazalhosseini, Yasser
Canada, Montreal
Université Mcgill
Roach, Jeffrey M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Roberts, Lewis Rowland
United Kingdom, Hinxton
Wellcome Sanger Institute
Statistics
Citations: 40
Authors: 323
Affiliations: 320
Identifiers
Doi:
10.1038/s41467-019-13885-w
ISSN:
20411723
Research Areas
Cancer
Genetics And Genomics
Health System And Policy