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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Low treatment initiation rates among multidrug-resistant tuberculosis patients in Gauteng, South Africa, 2011
International Journal of Tuberculosis and Lung Disease, Volume 17, No. 8, Year 2013
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Description
SETTING: Gauteng, South Africa. OBJECTIVE: To determine treatment uptake among newly diagnosed multidrug-resistant tuberculosis (MDRTB) patients and risk markers for non-initiation of treatment. DESIGN: A cross-sectional study was conducted including all newly diagnosed MDR-TB patients in Gauteng Province, South Africa, in 2011. Socio-demographic and clinical characteristics of those who attended Sizwe Hospital, the designated MDR-TB hospital, were extracted from their medical records. District health offices provided data on patients not seen at Sizwe Hospital. Univariate and multivariate analysis were used to determine risk markers for non-initiation of treatment. RESULTS: Of the 942 newly diagnosed MDR-TB patients in Gauteng, only 593 (63%) initiated treatment. Of these, 70 (11.8%) did not maintain treatment up to the fourth month. Among the 349 (37%) who did not initiate treatment, 31.2% died and 46.4% could not be accounted for. Referral for laboratory diagnosis from hospitals, health district of the laboratory diagnosis, human immunodeficiency virus infection and place of residence were independently associated with non-initiation of MDR-TB treatment. CONCLUSION: Untreated patients continue to transmit MDR-TB in the community. These study findings highlight the need to identify and target the causes of noninitiation of treatment in specific settings. © 2013 The Union.
Authors & Co-Authors
Ebonwu, Joy I.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Pretoria
University of Pretoria
Tint, Khin San
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Pretoria
University of Pretoria
Ihekweazu, Chikwe A.
South Africa, Johannesburg
National Health Laboratory Service
United Kingdom, London
Public Health England
Statistics
Citations: 24
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.5588/ijtld.13.0071
ISSN:
10273719
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
South Africa