Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
IRF-1 responsiveness to IFN-γ predicts different cancer immune phenotypes
British Journal of Cancer, Volume 109, No. 1, Year 2013
Notification
URL copied to clipboard!
Description
Background:Several lines of evidence suggest a dichotomy between immune active and quiescent cancers, with the former associated with a good prognostic phenotype and better responsiveness to immunotherapy. Central to such dichotomy is the master regulator of the acute inflammatory process interferon regulatory factor (IRF)-1. However, it remains unknown whether the responsiveness of IRF-1 to cytokines is able to differentiate cancer immune phenotypes.Methods:IRF-1 activation was measured in 15 melanoma cell lines at basal level and after treatment with IFN-γ, TNF-α and a combination of both. Microarray analysis was used to compare transcriptional patterns between cell lines characterised by high or low IRF-1 activation.Results:We observed a strong positive correlation between IRF-1 activation at basal level and after IFN-γ and TNF-α treatment. Microarray demonstrated that three cell lines with low and three with high IRF-1 inducible translocation scores differed in the expression of 597 transcripts. Functional interpretation analysis showed mTOR and Wnt/β-cathenin as the top downregulated pathways in the cell lines with low inducible IRF-1 activation, suggesting that a low IRF-1 inducibility recapitulates a cancer phenotype already described in literature characterised by poor prognosis.Conclusion:Our findings support the central role of IRF-1 in influencing different tumour phenotypes. © 2013 Cancer Research UK. All rights reserved.
Authors & Co-Authors
Murtas, Daniela
United States, Bethesda
National Institutes of Health Nih
Italy, Cagliari
Università Degli Studi Di Cagliari
Maric, Dragan A.
United States, Bethesda
National Institute of Neurological Disorders and Stroke
Filie, Armando Carlos
United States, Rockville
National Cancer Institute Nci
Bedognetti, Davide
United States, Bethesda
National Institutes of Health Nih
Chouchane, Lotfi
Qatar, Doha
Weill Cornell Medicine-qatar
Wang, Ena
United States, Bethesda
National Institutes of Health Nih
Marincola, Franco Maria
United States, Bethesda
National Institutes of Health Nih
Qatar, Doha
Sidra Medicine
Statistics
Citations: 53
Authors: 7
Affiliations: 10
Identifiers
Doi:
10.1038/bjc.2013.335
ISSN:
15321827
Research Areas
Cancer