Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review
BMC Public Health, Volume 9, Article 450, Year 2009
Notification
URL copied to clipboard!
Description
Abstract. Background. In 2004, tuberculosis (TB) was responsible for 2.5% of global mortality (among men 3.1%; among women 1.8%) and 2.2% of global burden of disease (men 2.7%; women 1.7%). The present work portrays accumulated evidence on the association between alcohol consumption and TB with the aim to clarify the nature of the relationship. Methods. A systematic review of existing scientific data on the association between alcohol consumption and TB, and on studies relevant for clarification of causality was undertaken. Results. There is a strong association between heavy alcohol use/alcohol use disorders (AUD) and TB. A meta-analysis on the risk of TB for these factors yielded a pooled relative risk of 2.94 (95% CI: 1.89-4.59). Numerous studies show pathogenic impact of alcohol on the immune system causing susceptibility to TB among heavy drinkers. In addition, there are potential social pathways linking AUD and TB. Heavy alcohol use strongly influences both the incidence and the outcome of the disease and was found to be linked to altered pharmacokinetics of medicines used in treatment of TB, social marginalization and drift, higher rate of re-infection, higher rate of treatment defaults and development of drug-resistant forms of TB. Based on the available data, about 10% of the TB cases globally were estimated to be attributable to alcohol. Conclusion. The epidemiological and other evidence presented indicates that heavy alcohol use/AUD constitute a risk factor for incidence and re-infection of TB. Consequences for prevention and clinical interventions are discussed. © 2009 Rehm et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2796667/bin/1471-2458-9-450-S1.PDF
https://efashare.b-cdn.net/share/pmc/articles/PMC2796667/bin/1471-2458-9-450-S2.PDF
Authors & Co-Authors
Rehm, Jurgen T.
Canada, Toronto
Centre for Addiction and Mental Health
Canada, Toronto
University of Toronto
Switzerland, Zurich
Head who Collaboration Centre for Substance Abuse
Germany, Dresden
Technische Universität Dresden
Samokhvalov, Andriy V.
Canada, Toronto
Centre for Addiction and Mental Health
Neuman, Manuela G.
Canada, Toronto
University of Toronto
Room, Robin G.W.
Australia, Melbourne
University of Melbourne
Australia, Fitzroy
Turning Point Alcohol and Drug Centre Inc
Parry, Charles D.H.
South Africa, Tygerberg
South African Medical Research Council
South Africa, Stellenbosch
Stellenbosch University
Lö̈nnroth, Knut
Switzerland, Geneva
Organisation Mondiale de la Santé
Patra, Jayadeep
Canada, Toronto
Centre for Addiction and Mental Health
Poznyak, Vladimir B.
Switzerland, Geneva
Organisation Mondiale de la Santé
Popova, Svetlana R.
Canada, Toronto
Centre for Addiction and Mental Health
Canada, Toronto
University of Toronto
Statistics
Citations: 9
Authors: 9
Affiliations: 9
Identifiers
Doi:
10.1186/1471-2458-9-450
e-ISSN:
14712458
Research Areas
Infectious Diseases
Substance Abuse
Study Design
Cohort Study
Study Approach
Systematic review
Participants Gender
Male
Female