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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Case report: Encephalopathy after ivermectin treatment in a patient infected with Loa loa and Plasmodium spp.
American Journal of Tropical Medicine and Hygiene, Volume 78, No. 4, Year 2008
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Description
Despite over 350 million people being safely treated with ivermectin, there have been rare cases of death post-treatment; these events are most often associated with high Loa loa microfilaremia. This first autopsy description of an encephalopathy case following the administration of ivermectin involves a 45-year-old male who became comatose 3 days after treatment. He slowly deteriorated over 5 weeks and died at 54 days after the anthelminthic treatment, probably as a result of a secondary skin or pulmonary infection exacerbated by malnutrition. The major pre- and post-autopsy findings included the presence of high loads of Loa loa, positivity for Plasmodium, the presence of a longstanding respiratory condition, and vascular pathology in the brain. The central nervous system lesions have similarities with those described in previously reported cases of Loa loa-associated death following diethylcarbamazine treatment. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Kamgno, Joseph
Cameroon, Yaounde
National Onchoceriasis Task Force
Boussinesq, Michel
France, Marseille
Ird Institut de Recherche Pour le Developpement
Labrousse, François J.
France, Limoges
Hopital Dupuytren
Nkegoum, Blaise
Cameroon, Yaounde
National Onchoceriasis Task Force
Thylefors, Björn I.
United States, Decatur
Mectizan Donation Program
MacKenzie, Charles D.
United States, East Lansing
Michigan State University
Statistics
Citations: 56
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2008.78.546
ISSN:
00029637
Research Areas
Food Security
Health System And Policy
Participants Gender
Male