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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Serologic evidence of human orthopoxvirus infections in Sierra Leone
BMC Research Notes, Volume 4, Article 465, Year 2011
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Description
Background: Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986. We conducted a serosurvey to determine whether human exposure to orthopoxviruses continues to occur in eastern Sierra Leone. Findings. To examine evidence of exposure to orthopoxviruses in the Kenema District of Sierra Leone, we collected and tested sera from 1596 persons by IgG ELISA and a subset of 313 by IgM capture ELISA. Eleven persons born after the cessation of smallpox vaccination had high orthopoxvirus-specific IgG values, and an additional 6 persons had positive IgM responses. No geographic clustering was noted. Conclusions: These data suggest that orthopoxviruses continue to circulate in Sierra Leone. Studies aimed at obtaining orthopoxvirus isolates and/or genetic sequences from rodents and symptomatic humans in the area are indicated. © 2011 MacNeil et al; licensee BioMed Central Ltd.
Authors & Co-Authors
MacNeil, Adam P.
United States, Atlanta
Centers for Disease Control and Prevention
Abel, Jason A.
United States, Atlanta
Centers for Disease Control and Prevention
Reynolds, Mary G.
United States, Atlanta
Centers for Disease Control and Prevention
Lash, R. Ryan
United States, Atlanta
Centers for Disease Control and Prevention
Fonnie, Richard
Sierra Leone, Freetown
Kenema Government Hospital
Kanneh, Lansana D.
Sierra Leone, Freetown
Kenema Government Hospital
Robert, Willie
Sierra Leone, Freetown
Kenema Government Hospital
Lungay, Victor K.
Sierra Leone, Freetown
Kenema Government Hospital
Goba, Augustine
Sierra Leone, Freetown
Kenema Government Hospital
Moses, Lina M.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Damon, Inger K.
United States, Atlanta
Centers for Disease Control and Prevention
Karem, Kevin L.
United States, Atlanta
Centers for Disease Control and Prevention
Bausch, Daniel G.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Statistics
Citations: 27
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1186/1756-0500-4-465
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Sierra Leone