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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
Nature, Volume 479, No. 7372, Year 2011
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Description
The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also live in full darkness, at low oxygen and high carbon dioxide concentrations, and are unable to sustain thermogenesis nor feel certain types of pain. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat's exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research. © 2011 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Kim, Eun-bae
South Korea, Seoul
Ewha Womans University
Fang, Xiaodong
China, Shenzhen
Bgi-shenzhen
Huang, Zhiyong
China, Shenzhen
Bgi-shenzhen
Lobanov, Alexei V.
United States, Boston
Harvard Medical School
Han, Lijuan
China, Shenzhen
Bgi-shenzhen
Turanov, Anton A.
United States, Boston
Harvard Medical School
Yang, Pengcheng
China, Shenzhen
Bgi-shenzhen
Yim, Sun-hee
United States, Boston
Harvard Medical School
Zhao, Xiang
China, Shenzhen
Bgi-shenzhen
Polak, Paz P.
United States, Boston
Harvard Medical School
Xiong, Zhiqiang
China, Shenzhen
Bgi-shenzhen
Zhu, Yabing
China, Shenzhen
Bgi-shenzhen
Kryukov, Gregory V.
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
Peshkin, Leonid
United States, Boston
Harvard Medical School
Yang, Lan
China, Shenzhen
Bgi-shenzhen
Bronson, Roderick T.
United States, Boston
Harvard Medical School
Buffenstein, Rochelle B.
United States, San Antonio
University of Texas Health Science Center at San Antonio
Zhao, Wei
China, Shenzhen
Bgi-shenzhen
Sunyaev, Shamil R.
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
Park, Thomas J.
United States, Chicago
University of Illinois at Chicago
Zhang, Guojie
China, Shenzhen
Bgi-shenzhen
Wang, Jun
China, Shenzhen
Bgi-shenzhen
Denmark, Copenhagen
Københavns Universitet
Gladyshev, Vadim N.
South Korea, Seoul
Ewha Womans University
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
Statistics
Citations: 445
Authors: 23
Affiliations: 7
Identifiers
Doi:
10.1038/nature10533
ISSN:
14764687
Research Areas
Cancer
Environmental
Sexual And Reproductive Health
Participants Gender
Female