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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75
Cell Host and Microbe, Volume 30, No. 11, Year 2022
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Description
Recently emerged SARS-CoV-2 Omicron subvariant, BA.2.75, displayed a growth advantage over circulating BA.2.38, BA.2.76, and BA.5 in India. However, the underlying mechanisms for enhanced infectivity, especially compared with BA.5, remain unclear. Here, we show that BA.2.75 exhibits substantially higher affinity for host receptor angiotensin-converting enzyme 2 (ACE2) than BA.5 and other variants. Structural analyses of BA.2.75 spike shows its decreased thermostability and increased frequency of the receptor binding domain (RBD) in the “up” conformation under acidic conditions, suggesting enhanced low-pH-endosomal cell entry. Relative to BA.4/BA.5, BA.2.75 exhibits reduced evasion of humoral immunity from BA.1/BA.2 breakthrough-infection convalescent plasma but greater evasion of Delta breakthrough-infection convalescent plasma. BA.5 breakthrough-infection plasma also exhibits weaker neutralization against BA.2.75 than BA.5, mainly due to BA.2.75’s distinct neutralizing antibody (NAb) escape pattern. Antibody therapeutics Evusheld and Bebtelovimab remain effective against BA.2.75. These results suggest BA.2.75 may prevail after BA.4/BA.5, and its increased receptor-binding capability could support further immune-evasive mutations. © 2022 The Author(s)
Authors & Co-Authors
Wang, Lei
China, Beijing
Chinese Academy of Sciences
An, Ran
China, Beijing
Changping Laboratory
Meng, Bo
United Kingdom, Cambridge
University of Cambridge
Gupta, Ravindra K.
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 60
Authors: 4
Affiliations: 6
Identifiers
Doi:
10.1016/j.chom.2022.09.018
ISSN:
19313128