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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The rise and fall of epidemic Neisseria meningitidis serogroup W135 meningitis in Burkina Faso, 2002-2005
Clinical Infectious Diseases, Volume 43, No. 7, Year 2006
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Description
Background. During the period 2001-2002, Burkina Faso reported its first meningitis epidemic due to Neisseria meningitidis (Nm) serogroup W135, prompting concerns that this serogroup would persist as a cause of epidemic disease. Methods. During the period 2002-2005, hospital- and population-based surveillances were conducted in 3 districts in Burkina Faso. Etiology was determined by culture, polymerase chain reaction (PCR), and latex agglutination. Reference laboratories determined phenotype and genotype. Results. Of 2004 subjects who received a lumbar puncture, 265 were identified as having Nm, including 93 who had Nm serogroup A (NmA) and 146 who had Nm serogroup W135 (NmW135). Over the study period, the proportion of cases due to NmW135 decreased by >75%, primarily because of decreased occurrence among young children and in a single district. During peak epidemic months, the annualized incidence of NmW135 decreased from 146 cases to <1 case per 100,000 population. All but 2 NmW135 isolates were phenotype W135: 2a:P1.5,2 (sequence type [ST]-11 clonal complex). All NmA isolates were phenotype A:4:P1-9 (ST-2859 of the ST-5 clonal complex). We identified 1 isolate from serogroup Y (ST-11 clonal complex), 1 isolate from serogroup X that was similar to strains previously associated with epidemic disease, and 1 isolate from serogroup W135 of the newly described ST-4375 complex. Conclusions. For unknown reasons, serogroup W135 achieved epidemic status, primarily among young children, and then largely disappeared over a short time period. The continued circulation of multiple strains with epidemic potential emphasizes the need for ongoing surveillance and the potential benefit of vaccines that are protective across serogroups. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Traoré, Yves
Burkina Faso, Ouagadougou
University of Ouagadougou
Njanpop-Lafourcade, Berthe Marie
France, Marseille
Agence de Médecine Préventive
Adjogblé, K.
Togo, Lome
Ministère de la Santé
Lourd, Mathilde
France, Marseille
Agence de Médecine Préventive
Yaro, Seydou
Burkina Faso, Ouagadougou
Centre Muraz
Nacro, Boubacar
Burkina Faso, Bobo-dioulasso
Centre Hospitalier National Souro Sanou
Drabo, Aly
Burkina Faso, Ouagadougou
Centre Muraz
Du Châtelet, Isabelle Parent
France, Marseille
Agence de Médecine Préventive
Mueller, Judith E.
France, Marseille
Agence de Médecine Préventive
Taha, Muhamed Kheir
France, Paris
Institut Pasteur, Paris
Borrow, Ray
United Kingdom, London
Public Health England
Nicolas, Pierre
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Alonso, Jean Michel
France, Paris
Institut Pasteur, Paris
Gessner, Bradford D.
France, Marseille
Agence de Médecine Préventive
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 88
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1086/507339
ISSN:
10584838
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Burkina Faso