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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Enhanced toll-like receptor responsiveness associated with mitogen-activated protein kinase activation in Plasmodium falciparum-infected children
Infection and Immunity, Volume 76, No. 11, Year 2008
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Description
Acute Plasmodium falciparum infection is associated with strongly upregulated cytokine responses that are at least partly the result of activation of Toll-like receptors (TLRs). Whether and how TLR expression/responsiveness changes upon malarial infection is, however, currently not well understood. To assess this, we examined expression of TLRs and used the TLR ligand lipopolysaccharide (LPS) and Pam3Cys to stimulate peripheral blood mononuclear cells (PBMCs) from Ghanaian schoolchildren who live in a rural area where P. falciparum is endemic. Expression of TLR2 was higher, and responses to its ligand, Pam3Cys, were enhanced in P. falciparum-infected children compared to their uninfected counterparts. In cells from the same children, stimulation by Pam3Cys resulted in higher p38 mitogen-activated protein kinase activation and higher cytokine production. In vitro experiments confirmed that preincubation of PBMCs with P. falciparum-infected red blood cells enhanced responsiveness to TLR ligands. Taken together, the data indicate that P. falciparum-infected children in areas where malaria is endemic have an altered innate immune system, which might be important for the balance between immunity and pathology when new infections are encountered or when novel vaccines are introduced. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Hartgers, Franca C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Obeng, Benedicta Baffoah
Netherlands, Leiden
Leids Universitair Medisch Centrum
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Voskamp, Astrid L.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Larbi, Irene A.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Amoah, Abena Serwaa
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Luty, A. J.F.
Netherlands, Nijmegen
Radboud University Medical Center
Boakye, Daniel Adjei
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Yazdanbakhsh, Maria M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Statistics
Citations: 50
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1128/IAI.01579-07
ISSN:
00199567
Research Areas
Infectious Diseases
Maternal And Child Health