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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Hormonal contraceptive use and HIV-1 infection in a population-based cohort in Rakai, Uganda
AIDS, Volume 17, No. 2, Year 2003
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Description
Background: Hormonal contraceptives have been associated with increased risk of HIV acquisition. Methods: The association between hormonal contraception use and HIV acquisition was assessed in a rural community-based cohort in Rakai District, Uganda. A group of 5117 sexually active HIV-negative women were surveyed at 10 month intervals between 1994 and 1999. Information on demographic and sociobehavioral characteristics, use of hormonal contraception (pill and injectable methods), condoms and the number of sexual partners was obtained by home-based interview. HIV incidence rate ratios (IRR) and 95% confidence intervals (CI) associated with hormonal contraception were estimated by multivariate Poisson regression after adjustment for age, condom use, number of sexual partners, marital status, education and history of genital ulcer disease. Results: At one or more interviews, 16.6% of women reported use of hormonal contraceptives and 23.0% reported condom use. HIV incidence was 2.3/100 person-years in hormonal contraceptive users compared with 1.5/100 person-years in non-hormonal contraceptive users (unadjusted IRR, 1.56; 95% CI, 1.00-2.33). After multivariate adjustment, the IRR associated with hormonal contraceptives was reduced to 0.94 (95% CI, 0.53-1.64). The adjusted IRR was 1.12 (95% CI, 0.48-2.56) with oral contraceptive use and 0.84 (95% CI, 0.41-1.72) with injectable methods. Conclusion: Use of hormonal contraception is not associated with HIV acquisition after adjustment for behavioral confounding. © 2003 Lippincott Williams & Wilkins.
Authors & Co-Authors
Kiddugavu, Mohammed G.
Uganda, Entebbe
Uganda Virus Research Institute
Makumbi, Fredrick Edward
Uganda, Entebbe
Uganda Virus Research Institute
Wawer, Maria J.
United States, New York
Mailman School of Public Health
Serwadda, David Musoke
Uganda, Kampala
Makerere University
Sewankambo, Nelson K.
Uganda, Kampala
Makerere University
Wabwire-Mangen, Fred
Uganda, Kampala
Makerere University
Lutalo, Tom
Uganda, Entebbe
Uganda Virus Research Institute
Meehan, Mary P.
United States, New York
Mailman School of Public Health
Xianbin,
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gray, Ronald H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Kiwanuka, Noah
Unknown Affiliation
Kigozi, Godfrey G.
Unknown Affiliation
Nalugoda, Fred Kakaire
Unknown Affiliation
Chen, Michael Z.
Unknown Affiliation
Mabirizi, Joseph
Unknown Affiliation
Mondo, George E.
Unknown Affiliation
Statistics
Citations: 120
Authors: 16
Affiliations: 4
Identifiers
Doi:
10.1097/00002030-200301240-00014
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Uganda
Participants Gender
Female