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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Topical eugenol successfully treats experimental candida albicans -induced keratitis
Ophthalmic Research, Volume 60, No. 2, Year 2018
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Description
Purpose: To determine the efficacy of eugenol for the treatment of Candida keratitis in an experimental model. Methods: The in vitro antifungal activity of eugenol and fluconazole was tested against C. albicans strains via the microbroth dilution method. An experimental model of Candida albicans keratitis was used. Rabbits were classified into those that received no treatment (control; group 1) and those that started eugenol treatment immediately (group 2) or after 4 days (group 3) of keratitis induction (n = 12-16 rabbits/group). The 2 treatment groups were assigned to 50 μL of 4 mg/mL eugenol drops hourly for 15 days, while the control group received saline. Corneal penetration of eugenol was measured using HPLC, and corneal toxicity was evaluated clinically and histopathologically. Results: The in vitro minimum inhibitory concentrations of eugenol and fluconazole against C. albicans were 2 and > 0.4 mg/mL, respectively. A 4-mg/mL preparation of eugenol in propylene glycol was the maximum nontoxic dose on rabbit corneas as suggested by clinical and histopathologic findings. At least 75% of all eugenol-treated eyes recovered from keratitis, with improvement in the remaining 25% of the eyes compared to controls. Conclusions: Eugenol can act as a natural, safe, and effective treatment for fungal keratitis, regardless of whether treatment is started immediately or after 4 days of keratitis induction. © 2018 S. Karger AG, Basel. All rights reserved.
Authors & Co-Authors
Hassan, Heba Ali
Egypt, New Minia
Deraya University
Geniady, Mahmoud M.
Egypt, Minya
Minia University
Abdelwahab, Sayed F.
Egypt, Minya
Minia University
Abd-Elghany, Manal I.
Egypt, Minya
Minia University
Sarhan, Hatem Abdelmonsef A.
Egypt, Minya
Minia University
Abdelghany, Ahmed A.
Egypt, Minya
Minia University
Kamel, Mohamed S.
Egypt, New Minia
Deraya University
Rodríguez, Alejandra E.
Spain, Alicante
Instituto Oftalmologico de Alicante
Alió, Jorge L.
Spain, Alicante
Instituto Oftalmologico de Alicante
Spain, Elche
Universidad Miguel Hernández de Elche
Statistics
Citations: 12
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1159/000488907
ISSN:
00303747
Study Design
Randomised Control Trial