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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Mutagenic effect, antioxidant and anticancer activities of six medicinal plants from Burkina Faso
Natural Product Research, Volume 26, No. 6, Year 2012
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Description
The antiproliferative activities of six medicinal plant extracts from Burkina Faso were evaluated in order to justify their traditional use for the treatment of cancer. The SOS chromotest method was used in vitro on Escherichia coli PQ37 to evaluate the mutagenic effect of the plant extracts. The DPPH method was used to evaluate the antioxidant activity of each plant. The antiproliferative activity was evaluated by MTS method on normal cells (Vero and MCR5) and cancer cells (KB) in contact with the extracts for 72 h. The results showed that the studied plants are not genotoxic. Lantana ukambensis and Acacia macrostachya induced a very significant antiproliferative effect against cancer cells with 94% and 95%, respectively. They also developed a strong antioxidant activity. The IC 50 values were 5.96±0.40 μg mL -1 for L. ukambensis and 4.30±0.26 μg mL -1 for A. macrostachya. These two plants are therefore potential sources for isolating new antioxidant and anticancer molecules. © 2012 Taylor & Francis.
Authors & Co-Authors
Sawadogo, Wamtinga Richard
Burkina Faso, Ouagadougou
University of Ouagadougou
France, Limoges
Laboratoire de Chimie Des Substances Naturelles
Maciuk, Alexandre
France, Limoges
Laboratoire de Chimie Des Substances Naturelles
Banzouzi, Jean Théophile
France, Paris
Cnrs Centre National de la Recherche Scientifique
Champy, Pierre
France, Limoges
Laboratoire de Chimie Des Substances Naturelles
Figadére, Bruno A.
France, Limoges
Laboratoire de Chimie Des Substances Naturelles
Guissou, Innocent Pierre
Burkina Faso, Ouagadougou
University of Ouagadougou
Nacoulma, Odile Germaine
Burkina Faso, Ouagadougou
University of Ouagadougou
Statistics
Citations: 52
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1080/14786419.2010.534737
ISSN:
14786419
e-ISSN:
14786427
Research Areas
Cancer
Study Locations
Burkina Faso