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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
HLA class i allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster
Tissue Antigens, Volume 73, No. 3, Year 2009
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Description
: The objective of this study was to characterize the class I human leukocyte antigen (HLA) genetic composition of the Ugandan population to better define its relationship with other African groups. Samples from 175 individuals from Kampala (Uganda) were subjected to class I HLA-A, -B, and -C sequence-based typing. The high concordance between the major alleles and haplotypes found in the current and Kenyan populations and interpopulation genetic distance analysis strongly supported the presence of an East African cluster that contained the current Ugandan population along with Kenyan Luo and Nandi populations. The congruence of major alleles in different populations would permit consideration of East Africa as an integrated setting when designing and evaluating much needed malaria, tuberculosis, and AIDS vaccines. © 2009 John Wiley & Sons A/S.
Authors & Co-Authors
Kijak, Gustavo Hernán
United States, Rockville
Hjf
Walsh, A. M.
United States, Rockville
Hjf
Lenzi, Rebecca
United States, Rockville
Hjf
Moqueet, N.
United States, Rockville
Hjf
Eller, Leigh Anne
Uganda, Kampala
Makerere University
Eller, Michael A.
Uganda, Kampala
Makerere University
Currier, Jeffrey R.
United States, Rockville
Hjf
Wang, Z.
United States, Rockville
Hjf
Wabwire-Mangen, Fred
Uganda, Kampala
Makerere University
Kibuuka, Hannah N.
Uganda, Kampala
Makerere University
Michael, Nelson L.
United States, Silver Spring
Walter Reed Army Institute of Research
Robb, Merlin Lee
United States, Rockville
Hjf
McCutchan, Francine E.
United States, Rockville
Hjf
Statistics
Citations: 44
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1111/j.1399-0039.2008.01192.x
ISSN:
00012815
e-ISSN:
13990039
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Uganda