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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Artesunate, a potential drug for treatment of Babesia infection
Parasitology International, Volume 59, No. 3, Year 2010
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Description
The effects of artesunate, a water-soluble artemisinin derivative, against Babesia species, including Babesia bovis, Babesia gibsoni and Babesia microti were studied. Cultures of B. bovis and B. gibsoni were treated with 0.26, 2.6, 26 and 260μM artesunate, showing inhibition of parasite growth at concentrations equal to and greater than 2.6μM artesunate by days 3 post-treatment for B. gibsoni and B. bovis in a dose-dependent manner. Consistent with in vitro experiments, artesunate was effective in the treatment of mice infected with B. microti at doses equal to and greater than 10. mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection. © 2010 Elsevier Ireland Ltd.
Authors & Co-Authors
Goo, Younkyoung
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Terkawi, Alaa Alaa
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Jia, Honglin
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Aboge, Gabriel Oluga
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Nelson, Bryce
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Kim, Suk
South Korea, Jinju
Gyeongsang National University
Igarashi, Ikuo
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Nishikawa, Yoshifumi
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Xuan, Xuenan
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Statistics
Citations: 48
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.parint.2010.06.004
ISSN:
13835769
Research Areas
Environmental