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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
ITIH-5 expression in human adipose tissue is increased in obesity
Obesity, Volume 20, No. 4, Year 2012
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Description
Adipocytes secrete many proteins that regulate metabolic functions. The gene inter-α (globulin) inhibitor H5 (ITIH-5) encodes a secreted protein and is known to be expressed abundantly in the placenta. However, using gene expression profiles data we observed high expression of ITIH-5 in adipose tissue. The aim of this study was to test the hypothesis that ITIH-5 is strongly expressed in human adipocytes and adipose tissue, and is related to obesity and clinical metabolic variables. ITIH-5 adipose tissue mRNA expression was analyzed with DNA microarray and real-time PCR, and its association with clinical variables was examined. ITIH-5 protein expression was analyzed using western blot. ITIH-5 mRNA expression was abundant in human adipose tissue, adipocytes, and placenta, and higher in subcutaneous (sc) compared to omental adipose tissue (P<0.0001). ITIH-5 mRNA and protein expression in sc adipose tissue were higher in obese compared to lean subjects (P<0.0001 and P<0.001, respectively). ITIH-5 mRNA expression was reduced after diet-induced weight loss (P<0.0001). ITIH-5 mRNA expression was associated with anthropometry and clinical metabolic variables. In conclusion, ITIH-5 is highly expressed in sc adipose tissue, increased in obesity, down regulated after weight loss, and associated with measures of body size and metabolism. Together, this indicates that ITIH-5 merits further investigation as a regulator of human metabolism. © 2011 The Obesity Society.
Authors & Co-Authors
Anveden, Åsa
Sweden, Gothenburg
Sahlgrenska Akademin
Sjöholm, Kajsa
Sweden, Gothenburg
Sahlgrenska Akademin
Jacobson, Peter
Sweden, Gothenburg
Sahlgrenska Akademin
Palsdottir, Vilborg
Sweden, Gothenburg
Sahlgrenska Akademin
Walley, Andrew J.
United Kingdom, London
Hammersmith Hospital
Froguel, Philippe
United Kingdom, London
Hammersmith Hospital
France, Lille
Epigénomique Fonctionnelle et Physiologie Moléculaire du Diabète et Maladies Associées
Al-Daghri, N. Mohammad
Saudi Arabia, Riyadh
College of Sciences
McTernan, Philip G.
United Kingdom, Coventry
University of Warwick
Mejhert, Niklas
Sweden, Stockholm
Karolinska Universitetssjukhuset
Arner, Peter
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sjostrom, Lars
Sweden, Gothenburg
Sahlgrenska Akademin
Carlsson, Lena M.S.
Sweden, Gothenburg
Sahlgrenska Akademin
Svensson, Per Arne
Sweden, Gothenburg
Sahlgrenska Akademin
Statistics
Citations: 30
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1038/oby.2011.268
ISSN:
19307381
e-ISSN:
1930739X
Research Areas
Genetics And Genomics
Noncommunicable Diseases