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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HIV-1 Autologous Antibody Neutralization Associates with Mother to Child Transmission
PLoS ONE, Volume 8, No. 7, Article e69274, Year 2013
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Description
The HIV-1 characteristics associated with mother to child transmission (MTCT) are still poorly understood and if known would indicate where intervention strategies should be targeted. In contrast to horizontally infected individuals, exposed infants possess inherited antibodies (Abs) from their mother with the potential to protect against infection. We investigated the HIV-1 gp160 envelope proteins from seven transmitting mothers (TM) whose children were infected either during gestation or soon after delivery and from four non-transmitting mothers (NTM) with similar viral loads and CD4 counts. Using pseudo-typed viruses we tested gp160 envelope glycoproteins for TZM-bl infectivity, CD4 and CCR5 interactions, DC-SIGN capture and transfer and neutralization with an array of common neutralizing Abs (NAbs) (2F5, 2G12, 4E10 and b12) as well as mother and infant plasma. We found no viral correlates associated with HIV-1 MTCT nor did we find differences in neutralization with the panel of NAbs. We did, however, find that TM possessed significantly higher plasma neutralization capacities than NTM (P = 0.002). Furthermore, we found that in utero (IU) TM had a higher neutralization capacity than mothers transmitting either peri-partum (PP) or via breastfeeding (BF) (P = 0.002). Plasma from children infected IU neutralized viruses carrying autologous gp160 viral envelopes as well as those from their corresponding mothers whilst plasma from children infected PP and/or BF demonstrated poor neutralizing capacity. Our results demonstrate heightened autologous NAb responses against gp120/gp41 can associate with a greater risk of HIV-1 MTCT and more specifically in those infants infected IU. Although the number of HIV-1 transmitting pairs is low our results indicate that autologous NAb responses in mothers and infants do not protect against MTCT and may in fact be detrimental when considering IU HIV-1 transmissions. © 2013 Baan et al.
Authors & Co-Authors
Baan, Elly
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
de Ronde, Anthony
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Stax, Martijn
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Sanders, Rogier W.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
United States, New York
Weill Cornell Medicine
Luchters, Stanley M.F.
Netherlands, Amsterdam
International Antiviral Therapy Evaluation Center Iatec
Australia, Melbourne
Burnet Institute
Australia, Clayton
Monash University
Vyankandondera, Joseph
Netherlands, Amsterdam
International Antiviral Therapy Evaluation Center Iatec
Rwanda, Kigali
Centre Hospitalier Universitaire de Kigali
Lange, Joep M.A.
Netherlands, Amsterdam
International Antiviral Therapy Evaluation Center Iatec
Pollakis, Georgios P.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Paxton, William A.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Statistics
Citations: 18
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0069274
e-ISSN:
19326203
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial