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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys
Journal of Psychosomatic Research, Volume 75, No. 2, Year 2013
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Description
Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities. Methods: Face-to-face household surveys conducted in 19 countries (n. = 52,095; person years. = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset. Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities. Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset. These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders. © 2013 Elsevier Inc.
Authors & Co-Authors
Scott, Kate Margaret
New Zealand, Dunedin
University of Otago
Alonso Caballero, J. L.
Spain, Barcelona
Hospital Del Mar
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Jonge, Peter de
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Viana, Maria Carmen
Brazil, Vitoria
Universidade Federal do Espírito Santo
Liu, Zhaourui
China, Beijing
Peking University Sixth Hospital
O'Neill, Siobhán M.
United Kingdom, Coleraine
Ulster University
Aguilar-Gaxiola, Sergio A.
United States, Davis
University of California, Davis
Bruffaerts, Ronny
Belgium, Leuven
Ku Leuven
Caldas-de-Almeida, José M.
Portugal, Lisbon
Universidade Nova de Lisboa
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
Angermeyer, Matthias Claus
Austria, Gosim
Center for Public Mental Health
Benjet, Corina L.
Mexico, Mexico
Instituto Nacional de Psiquiatría Ramon de la Fuente
de Girolamo, Giovanni
Italy, Brescia
Irccs Centro San Giovanni Di Dio Fatebenefratelli
Firuleasa, Ingrid Laura
Romania, Bucharest
National School of Public Health, Management and Professional Development
Hu, Chiyi
China, Shenzhen
Szu-shenzhen Kangning Hospital
Kiejna, Andrzej
Poland, Wroclaw
Wroclaw Medical University
Kovess - Masfety, Viviane
France, Paris
Université Paris Cité
Levinson, Daphna
Israel, Jerusalem
Mental Health Services Ministry of Health
Nakane, Yoshibumi
Japan, Sasebo
Nagasaki International University
Piazza, Marina
Peru, Lima
Universidad Peruana Cayetano Heredia
Posada-Villa, J. A.
Colombia, Bogota
Universidad Colegio Mayor de Cundinamarca
Khalaf, Mohammad
Iraq, Mosul
University of Mosul
Lim, Carmen C.W.
New Zealand, Dunedin
University of Otago
Kessler, Ronald C.
United States, Boston
Harvard Medical School
Statistics
Citations: 25
Authors: 24
Affiliations: 25
Identifiers
Doi:
10.1016/j.jpsychores.2013.04.007
ISSN:
00223999
Research Areas
Maternal And Child Health
Mental Health
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study