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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Whole-genome analysis reveals the complex evolutionary dynamics of Kenyan G2P[4] human rotavirus strains
Journal of General Virology, Volume 92, No. 9, Year 2011
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Description
Although G2P[4] rotaviruses are common causes of acute childhood diarrhoea in Africa, to date there are no reports on whole genomic analysis of African G2P[4] strains. In this study, the nearly complete genome sequences of two Kenyan G2P[4] strains, AK26 and D205, detected in 1982 and 1989, respectively, were analysed. Strain D205 exhibited a DS-1-like genotype constellation, whilst strain AK26 appeared to be an intergenogroup reassortant with a Wa-like NSP2 genotype on the DS-1-like genotype constellation. The VP2-4, VP6-7, NSP1, NSP3 and NSP5 genes of strain AK26 and the VP2, VP4, VP7 and NSP1-5 genes of strain D205 were closely related to those of the prototype or other human G2P[4] strains. In contrast, their remaining genes were distantly related, and, except for NSP2 of AK26, appeared to originate from or share a common origin with rotavirus genes of artiodactyl (ruminant and camelid) origin. These observations highlight the complex evolutionary dynamics of African G2P[4] rotaviruses. © 2011 SGM.
Authors & Co-Authors
Ghosh, Souvik
Japan, Sapporo
Sapporo Medical University School of Medicine
Adachi, Noriaki
Japan, Kushiro
Kushiro City General Hospital
Gatheru, Zippora
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
Gynae-paed Medical Centre
Nyangao, James W.O.
Kenya, Nairobi
Kenya Medical Research Institute
Yamamoto, Dai
Japan, Sapporo
Sapporo Medical University School of Medicine
Ishino, Masaho
Japan, Sapporo
Sapporo Medical University School of Medicine
Urushibara, Noriko
Japan, Sapporo
Sapporo Medical University School of Medicine
Kobayashi, Nobumichi
Japan, Sapporo
Sapporo Medical University School of Medicine
Statistics
Citations: 25
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1099/vir.0.033001-0
ISSN:
00221317
e-ISSN:
14652099
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health