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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The Kenya Form of Hereditary Persistence of Fetal Haemoglobin: Structural Studies and Evidence for Homogeneous Distribution of Haemoglobin F using Fluorescent Anti‐haemoglobin F Antibodies
British Journal of Haematology, Volume 32, No. 1, Year 1976
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Description
Several members of a Ugandan family were heterozygous for the γβ fusion gene of Haemoglobin Kenya. Levels of Hb Kenya were significantly higher than those in subjects of previous reports, ranging from 20.68 to 23.35% of the total haemoglobin. The individuals had also 5–8% Hb F, consisting solely of α and Gγ chains. Investigation of the distribution of Hb F among the red cells of Hb Kenya heterozygotes, using monospecific antibodies absorbed against pure Hb Kenya and rendered fluorescent by conjugation with fluorescein isothiocyanate, showed the presence of fetal haemoglobin in all red cells. The data suggest that the phenotype of the Hb Kenya trait resembles that of the Gγ form of hereditary persistence of fetal haemoglobin rather than that of thalassaemia. Copyright © 1976, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Nute, Peter E.
United States, Seattle
University of Washington
Uganda, Kampala
Uganda Cancer Institute
Wood, William G.
United States, Seattle
University of Washington
Uganda, Kampala
Uganda Cancer Institute
Stamatoyannopoulos, Georges
United States, Seattle
University of Washington
Uganda, Kampala
Uganda Cancer Institute
Olweny, Charles L.M.
United States, Seattle
University of Washington
Uganda, Kampala
Uganda Cancer Institute
Failkow, P. J.
United States, Seattle
University of Washington
Uganda, Kampala
Uganda Cancer Institute
Statistics
Citations: 29
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-2141.1976.tb01875.x
ISSN:
00071048
e-ISSN:
13652141
Research Areas
Genetics And Genomics
Study Locations
Kenya