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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Treatment of kaposi's sarcoma with a combination of actinomycin D and vincristine
Cancer, Volume 31, No. 6, Year 1973
Notification
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Description
Twenty‐four patients with aggressive forms of Kaposi's sarcoma were treated with either Actinomycin D or Actinomycin D plus vincristine in a randomized clinical trial. Of 10 patients in the actinomycin alone group there were 4 complete and 5 partial responses. Of 14 patients receiving the combination there were 10 complete and 3 partial responses. The relapse rate thus far is 25% and 40% in each group respectively. A correlation was voted between the clinical response, histology, and tumor size, and the possibility remains that the response differences in the two treatment groups may be independent of the treatment regimens. Nevertheless, both treatment schedules were well tolerated and the results of this trial have led to the design of a new trial testing the efficacy of three drug combination therapy in Kaposi's sarcoma. Copyright © 1973 American Cancer Society
Authors & Co-Authors
Vogel, Charles L.
Uganda, Kampala
Uganda Cancer Institute
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Rockville
National Cancer Institute Nci
Primack, Aron
Uganda, Kampala
Uganda Cancer Institute
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Rockville
National Cancer Institute Nci
Dhru, Dhaval S.
Uganda, Kampala
Uganda Cancer Institute
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Rockville
National Cancer Institute Nci
Briers, Peter
Uganda, Kampala
Uganda Cancer Institute
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Rockville
National Cancer Institute Nci
Owor, Raphael
Uganda, Kampala
Uganda Cancer Institute
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Rockville
National Cancer Institute Nci
Kyalwazi, Sebastian K.
Uganda, Kampala
Uganda Cancer Institute
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
United States, Rockville
National Cancer Institute Nci
Statistics
Citations: 44
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1002/1097-0142(197306)31:6<1382::AID-CNCR2820310613>3.0.CO;2-D
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Study Design
Randomised Control Trial