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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A novel structural effector from rust fungi is capable of fibril formation
Plant Journal, Volume 75, No. 5, Year 2013
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Description
It has been reported that filament-forming surface proteins such as hydrophobins are important virulence determinants in fungi and are secreted during pathogenesis. Such proteins have not yet been identified in obligate biotrophic pathogens such as rust fungi. Rust transferred protein 1 (RTP1p), a rust protein that is transferred into the host cytoplasm, accumulates around the haustorial complex. To investigate RTP1p structure and function, we used immunocytological, biochemical and computational approaches. We found that RTP1p accumulates in protuberances of the extra-haustorial matrix, a compartment that surrounds the haustorium and is separated from the plant cytoplasm by a modified host plasma membrane. Our analyses show that RTP1p is capable of forming filamentous structures in vitro and in vivo. We present evidence that filament formation is due to β-aggregation similar to what has been observed for amyloid-like proteins. Our findings reveal that RTP1p is a member of a new class of structural effectors. We hypothesize that RTP1p is transferred into the host to stabilize the host cell and protect the haustorium from degradation in later stages of the interaction. Thus, we provide evidence for transfer of an amyloid-like protein into the host cell, which has potential for the development of new resistance mechanisms against rust fungi. © 2013 John Wiley & Sons Ltd.
Authors & Co-Authors
Kemen, Eric M.
Germany, Koln
Max Planck Institute for Plant Breeding Research
Ehlers, Andreas Wolfgang
Germany, Konstanz
Universität Konstanz
Voegele, Ralf Thomas
Germany, Stuttgart
Universität Hohenheim
Statistics
Citations: 41
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1111/tpj.12237
ISSN:
1365313X