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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant
Journal of Virology, Volume 80, No. 2, Year 2006
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Description
Maternal passive immunity typically plays a critical role in protecting infants from new infections; however, the specific contribution of neutralizing antibodies in limiting mother-to-child transmission of human immunodeficiency virus type 1 is unclear. By examining cloned envelope variants from 12 transmission pairs, we found that vertically transmitted variants were more resistant to neutralization by maternal plasma than were maternal viral variants near the time of transmission. The vertically transmitted envelope variants were poorly neutralized by monoclonal antibodies biz, 2G12, 2F5, and 4E10 individually or in combination. Despite the fact that the infant viruses were among the most neutralization resistant in the mother, they had relatively few glycosylation sites. Moreover, the transmitted variants elicited de novo neutralizing antibodies in the infants, indicating that they were not inherently difficult to neutralize. The neutralization resistance of vertically transmitted viruses is in contrast to the relative neutralization sensitivity of viruses sexually transmitted within discordant couples, suggesting that the antigenic properties of viruses that are favored for transmission may differ depending upon mode of transmission. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Wu, Xueling
United States, Seattle
Fred Hutchinson Cancer Research Center
Parast, Adam B.
United States, Seattle
Fred Hutchinson Cancer Research Center
Richardson, Barbra Ann
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Nduati, Ruth W.
Kenya, Nairobi
University of Nairobi
John-Stewart, Grace C.
United States, Seattle
University of Washington
Mbori-Ngacha, Dorothy A.
Kenya, Nairobi
University of Nairobi
Rainwater, Stephanie M.J.
United States, Seattle
Fred Hutchinson Cancer Research Center
Overbaugh, Julie M.
United States, Seattle
Fred Hutchinson Cancer Research Center
Statistics
Citations: 287
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1128/JVI.80.2.835-844.2006
ISSN:
0022538X
Research Areas
Maternal And Child Health