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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of T
H
9 cells
Nature Immunology, Volume 15, No. 8, Year 2014
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Description
The TH9 subset of helper T cells was initially shown to contribute to the induction of autoimmune and allergic diseases, but subsequent evidence has suggested that these cells also exert antitumor activities. However, the molecular events that account for their effector properties are elusive. Here we found that the transcription factor IRF1 enhanced the effector function of TH9 cells and dictated their anticancer properties. Under TH9-skewing conditions, interleukin 1β (IL-1β) induced phosphorylation of the transcription factor STAT1 and subsequent expression of IRF1, which bound to the promoters of Il9 and Il21 and enhanced secretion of the cytokines IL-9 and IL-21 from TH9 cells. Furthermore, IL-1β-induced TH9 cells exerted potent anticancer functions in an IRF1- and IL-21-dependent manner. Our findings thus identify IRF1 as a target for controlling the function of TH9 cells. © 2014 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Végran, Frédérique
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Berger, Hélène
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Boidot, Romain
France, Dijon
Centre Georges-françois Leclerc
Mignot, Grégoire
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Bruchard, Mélanie
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Dosset, Magalie
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Chalmin, Fanny
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Rébé, Cédric
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Dérangère, Valentin
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Ryffel, Bernhard
France, Orleans
University and Cnrs
South Africa, Cape Town
University of Cape Town
Kato, Masashi
Japan, Nagoya
Nagoya University Graduate School of Medicine
Prévost-Blondel, Armelle
France, Paris
Institut Cochin
France, Paris
Université Paris Cité
Ghiringhelli, François
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Apétoh, Lionel
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Statistics
Citations: 14
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1038/ni.2925
ISSN:
15292908
e-ISSN:
15292916