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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults
Vaccine, Volume 26, No. 2, Year 2008
Notification
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Description
We evaluated EP HIV-1090 vaccine, a DNA plasmid encoding 21 cytotoxic T-lymphocyte (CTL) epitopes of human immunodeficiency virus type 1 (HIV-1) and the pan-DR helper T-lymphocyte epitope (PADRE), in a dose escalation, randomized, double-blinded, placebo-controlled Phase 1 trial. Vaccine, at 0.5, 2.0, or 4.0 mg doses, or placebo was injected four times over 6 months. Forty-two healthy, HIV-1-uninfected adults were enrolled. Using an interferon-γ ELISPOT assay, a response to PADRE was detected in one vaccine recipient. Three vaccine recipients raised anti-HIV-1 CD8+ CTL measured by chromium-release assay. The vaccine was safe and well-tolerated, but only weakly immunogenic. © 2007 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Gorse, Geoffrey J.
United States, St. Louis
Saint Louis University
United States, Seattle
Hiv Vaccine Trials Network
Baden, Lindsey Robert R.
United States, Boston
Harvard Medical School
United States, Seattle
Hiv Vaccine Trials Network
Wecker, Margaret
United States, Seattle
Hiv Vaccine Trials Network
Newman, Mark J.
United States, San Diego
Epimmune
United States, Seattle
Hiv Vaccine Trials Network
Ferrari, Guido
United States, Durham
Duke University
United States, Seattle
Hiv Vaccine Trials Network
Weinhold, Kent J.
United States, Durham
Duke University
United States, Seattle
Hiv Vaccine Trials Network
Livingston, Brian D.
United States, San Diego
Epimmune
United States, Seattle
Hiv Vaccine Trials Network
Villafana, Tonya L.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Seattle
Hiv Vaccine Trials Network
Li, Hongli
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
Hiv Vaccine Trials Network
Noonan, Elizabeth A.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
Hiv Vaccine Trials Network
Russell, Nina D.
United States, Seattle
Hiv Vaccine Trials Network
Statistics
Citations: 53
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.vaccine.2007.10.061
ISSN:
0264410X
Research Areas
Genetics And Genomics
Infectious Diseases