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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Assessing the relationship between HIV infection and cervical cancer in Côte d'Ivoire: A case-control study
BMC Infectious Diseases, Volume 10, Article 242, Year 2010
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Description
Background: The association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a case-control study in a West African population to assess the relationship between HIV infection and invasive cervical cancer, taking into account HPV infection and other potential risk factors for cervical cancer.Methods: Women with invasive cervical cancer (cases) or normal cervical cytology (controls) were recruited in a hospital-based case-control study in Abidjan, Côte d'Ivoire. Odds ratios and 95% confidence intervals (CI) were estimated in logistic regression analyses controlling for important cofactors.Results: HIV infection was noted in 22/132 (16.7%) cases and 10/120 (8.3%) controls (p = 0.048). High-risk HPV infection was detected in cervical tumor samples from 89.4% of case-participants and in cervical cytology samples in 31.1% of control-participants. In logistic regression analysis, HIV infection was associated with cervical cancer in women with HPV (OR 3.4; 95% CI 1.1-10.8). Among women aged ≤ 40 years, risk factors for cervical cancer were high-risk HPV infection (OR 49.3; 95% CI 8.2-295.7); parity > 2 (OR 7.0; 95% CI 1.9-25.7) and HIV infection (OR 4.5; 95% CI 1.5-13.6). Among women aged > 40 years, high-risk HPV infection (OR 23.5; 95% CI 9.1-60.6) and parity > 2 (OR 5.5; 95% CI 2.3-13.4), but association with HIV infection was not statistically significant.Conclusions: These data support the hypothesis that HIV infection is a cofactor for cervical cancer in women with HPV infection, and, as in all populations, the need for promoting cervical screening in populations with high prevalence of HIV infection. © 2010 Adjorlolo-Johnson et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Adjorlolo-Johnson, Georgette T.
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Unger, E. R.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Boni-Ouattara, Edith
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Touré-Coulibaly, Karidiata
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Maurice, Chantal E.
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
Vernon, Suzanne D.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Sissoko, Marcel
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Yopougon
Greenberg, Alan E.
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Wiktor, Stefan Zbyszko
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
United States, Atlanta
Centers for Disease Control and Prevention
Chorba, Terence L.
Cote D'ivoire, Abidjan
Project Retro-ci Abidjan
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Statistics
Citations: 56
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2334-10-242
e-ISSN:
14712334
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Ivory Coast
Participants Gender
Female