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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Reference values for clinical laboratory parameters in young adults in Maputo, Mozambique
PLoS ONE, Volume 9, No. 5, Article e97391, Year 2014
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Description
Background: Clinical laboratory reference values from North American and European populations are currently used in most Africans countries due to the absence of locally derived reference ranges, despite previous studies reporting significant differences between populations. Our aim was to define reference ranges for both genders in 18 to 24 year-old Mozambicans in preparation for clinical vaccine trials. Methods: A cross-sectional study including 257 volunteers (102 males and 155 females) between 18 and 24 years was performedat a youth clinic in Maputo, Mozambique. All volunteers were clinically healthy and human immunodeficiency virus, Hepatitis B virus and syphilis negative.Median and 95% reference ranges were calculated for immunological, hematological and chemistry parameters. Ranges were compared with those reported based on populations in other African countries and the US. The impact of applying US NIH Division of AIDS (DAIDS) toxicity tables was assessed. Results: The immunology ranges were comparable to those reported for the US and western Kenya.There were significant gender differences in CD4+ T cell values 713 cells/μL in males versus 824 cells/μL in females (p<0.0001). Hematologic values differed from the US values but were similar to reports of populations in western Kenya and Uganda. The lower and upper limits of the ranges for hemoglobin, hematocrit, red blood cells, white blood cells and lymphocytes were somewhat lower than those from these African countries. The chemistry values were comparable to US values, with few exceptions. The upper limits for ALT, AST, bilirubin, cholesterol and triglycerides were higher than those from the US. DAIDStables for adverse events predicted 297 adverse events and 159 (62%) of the volunteers would have been excluded. Conclusion: This study is the first to determine normal laboratory parameters in Mozambique. Our results underscore the necessity of establishing region-specific clinical reference ranges for proper patient management and safe conduct of clinical trials. © 2014 Tembe et al.
Authors & Co-Authors
Tembe, Nelson
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Sweden, Stockholm
Karolinska Institutet
Mozambique, Maputo
Universidade Eduardo Mondlane
Joaquim, Orvalho Augusto
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Alfai, Eunice R.
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Sitoe, Nádia E.
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Viegas, Edna Omar
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Sweden, Stockholm
Karolinska Institutet
Mozambique, Maputo
Universidade Eduardo Mondlane
Macovela, Eulália
Mozambique, Maputo
Universidade Eduardo Mondlane
Mozambique, Maputo
Hospital Central de Maputo
Gonçalves, Emilia
Mozambique, Maputo
Universidade Eduardo Mondlane
Mozambique, Maputo
Hospital Central de Maputo
Osman, Nafissa Bique
Mozambique, Maputo
Universidade Eduardo Mondlane
Mozambique, Maputo
Hospital Central de Maputo
Andersson, Sören
Sweden, Orebro
Universitetssjukhuset Örebro
Jani, Ilesh Vinodrai
Mozambique, Maputo
Instituto Nacional de Saude Maputo
Nilsson, Charlotta
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Statistics
Citations: 38
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0097391
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Kenya
Mozambique
Uganda
Participants Gender
Female