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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibody patterns to herpesviruses in Kaposi's sarcoma. II. Serological association of american Kaposi's sarcoma with cytomegalovirus
International Journal of Cancer, Volume 22, No. 2, Year 1978
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Description
The prominent finding of this extended serologic analysis on American and African Kaposi's sarcoma (KS) patients and appropriately matched control groups is the detection of a specific serologic association of cytomegalovirus (CMV) with American KS patients. All American KS sera contained CMV antibodies and their geometric mean titers (GMT) were significantly higher than those in sera of melanoma patients (GMT ratio k = 5.3 to 7.7 by complement fixation [CF], k = 8.9 by indirect hemagglutination [IHA]) or in sera of age‐ and sex‐matched healthy controls (k = 12.6 to 16.0 by CF, k = 12.6 by IHA). The result is strongly reminiscent of the data obtained previously for European KS. Although the GMT to CMV of African KS patients were similar to the GMT of the American KS groups, their significance cannot be demonstrated due to the high background of CMV infections in the control groups. Complex mechanisms are hypothesized, by analogy with the Epstein‐Barr virus (EBV) involvement in Burkitt's lymphoma (BL), for a CMV involvement in the development of KS. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Giraldo, Gaetano
United States, New York
Memorial Sloan-kettering Cancer Center
Beth, Elke
United States, New York
Memorial Sloan-kettering Cancer Center
Henle, Werner
United States, Philadelphia
University of Pennsylvania
Henle, Gertrude E.
United States, Philadelphia
University of Pennsylvania
Miká, V.
United States, New York
Memorial Sloan-kettering Cancer Center
Safai, Bijan
United States, New York
Memorial Sloan-kettering Cancer Center
Huraux, Jean Marie
France, Paris
Hôpital Universitaire Pitié Salpêtrière
McHardy, J.
Uganda, Nile
Kuluva Hospital
United Kingdom, Glasgow
Ruchill Hospital
De‐Thá, G.
France, Lyon
Centre International de Recherche Sur le Cancer
Statistics
Citations: 221
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1002/ijc.2910220204
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer