Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Case-Control Study of the Etiology of Infant Diarrheal Disease in 14 Districts in Madagascar
PLoS ONE, Volume 7, No. 9, Article e44533, Year 2012
Notification
URL copied to clipboard!
Description
Background: Acute diarrhea is a major cause of childhood morbidity and mortality worldwide. Its microbiological causes and clinico-epidemiological aspects were examined during the rainy seasons from 2008 to 2009 in 14 districts in Madagascar. Methods: Stool specimens of 2196 children with acute diarrhea and 496 healthy children were collected in a community setting. Intestinal parasites were diagnosed by microscopy and bacteria by culturing methods. Rota-, astro and adenoviruses were identified using commercially available ELISA kits and rotaviruses were confirmed using reverse transcriptase polymerase chain reaction (RT-PCR). Results: Intestinal microorganisms were isolated from 54.6% of diarrheal patients and 45.9% of healthy subjects (p = <0.01). The most common pathogens in diarrheic patients were intestinal parasites (36.5%). Campylobacter spp. and Rotavirus were detected in 9.7% and 6.7% of diarrheic patients. The detection rates of Entamoeba histolytica, Trichomonas intestinalis and Giardia lamblia were much greater in diarrheal patients than in non diarrheal subjects (odds ratios of 5.1, 3.2, 1.7 respectively). The abundance of other enteropathogens among the non diarrheal group may indicate prolonged excretion or limited pathogenicity. Conclusion: In developing countries, where the lack of laboratory capacities is great, cross sectional studies of enteropathogens and their spatial distribution, including diarrheal and non diarrheal subjects, are interesting tools in order to advise regional policies on treatment and diarrheic patient management. © 2012 Randremanana et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3444445/bin/pone.0044533.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3444445/bin/pone.0044533.s002.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3444445/bin/pone.0044533.s003.docx
Authors & Co-Authors
Randremanana, Rindra Vatosoa
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Randrianirina, Frédérique
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Gousseff, Marie
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Dubois, Natasha
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Razafindratsimandresy, Richter
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ratsima, Elisoa Hariniaina
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Garin, Benoît
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Randriamanantena, Arthur
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Rakotonirina, Hanitra Clara
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ramparany, Lovasoa
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ramarokoto, Charles Emile
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Rakotomanana, Fanjasoa
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ratsitorahina, Maherisoa
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Rajatonirina, Soatiana Cathycia
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Talarmin, Antoine
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Richard, Vincent
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Statistics
Citations: 50
Authors: 16
Affiliations: 1
Identifiers
Doi:
10.1371/journal.pone.0044533
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Madagascar