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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials
Ultrasound in Obstetrics and Gynecology, Volume 55, No. 1, Year 2020
Notification
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Description
Objective: To explore the effect on perinatal outcome of different fetal monitoring strategies for early-onset fetal growth restriction (FGR). Methods: This was a cohort analysis of individual participant data from two European multicenter trials of fetal monitoring methods for FGR: the Growth Restriction Intervention Study (GRIT) and the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE). All women from GRIT (n = 238) and TRUFFLE (n = 503) who were randomized between 26 and 32 weeks' gestation were included. The women were grouped according to intervention and monitoring method: immediate delivery (GRIT) or delayed delivery with monitoring by conventional cardiotocography (CTG) (GRIT), computerized CTG (cCTG) only (GRIT and TRUFFLE) or cCTG and ductus venosus (DV) Doppler (TRUFFLE). The primary outcome was survival without neurodevelopmental impairment at 2 years of age. Results: Gestational age at delivery and birth weight were similar in both studies. Fetal death rate was similar between the GRIT and TRUFFLE groups, but neonatal and late death were more frequent in GRIT (18% vs 6%; P < 0.01). The rate of survival without impairment at 2 years was lowest in pregnancies that underwent immediate delivery (70% (95% CI, 61–78%)) or delayed delivery with monitoring by CTG (69% (95% CI, 57–82%)), increased in those monitored using cCTG only in both GRIT (80% (95% CI, 68–91%)) and TRUFFLE (77% (95% CI, 70–84%)), and was highest in pregnancies monitored using cCTG and DV Doppler (84% (95% CI, 80–89%)) (P < 0.01 for trend). Conclusions: This analysis supports the hypothesis that the optimal method for fetal monitoring in pregnancies complicated by early-onset FGR is a combination of cCTG and DV Doppler assessment. Trial Registration: GRIT ISRCTN41358726 and TRUFFLE ISRCTN56204499. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
Authors & Co-Authors
Ganzevoort, Wessel J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Thornton, Jim G.
United Kingdom, Nottingham
University of Nottingham Medical School
Marlow, Neil
United Kingdom, London
University College London
Thilaganathan, B.
United Kingdom, London
St George's University Hospitals Nhs Foundation Trust
United Kingdom, London
St George’s, University of London
Arabin, Birgit
Germany, Marburg
Philipps-universität Marburg
Prefumo, Federico
Italy, Brescia
Università Degli Studi Di Brescia
Lees, Christoph C.
United Kingdom, Cambridge
Rosie Hospital
Belgium, Leuven
Ku Leuven
Wolf, H.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Van Bulck, B.
Belgium, Verviers
Ziekenhuisnetwerk Antwerpen
Kalakoutis, G. M.
Cyprus, Nicosia
Archbishop Makarios Iii Hospital
Sak, P.
Czech Republic, Hradec Kralove
Czech Republic—ceske Budejovice
Schneider, K. T.M.
Germany, Munich
Ludwig-maximilians-universität München
Karpathios, S. E.
Greece, Athens
Greece
Major, Tamás
Unknown Affiliation
Todros, Tullia
Unknown Affiliation
Arduini, D.
Italy, Rome
Fatebenefratelli
Flumini, C.
Italy, Ancona
Ospedale Pediatrico G. Salesi
Tenore, A. C.
Italy, Como
Ospedale Valduce
Roncaglia, N.
Italy, Milan
Università Degli Studi Di Milano-bicocca
Frusca, Tiziana
Italy, Brescia
Università Degli Studi Di Brescia
Italy, Parma
Azienda Ospedaliero-universitaria Di Parma
Ferretti, G.
Italy, San Miniato
Irccs Fondazione Stella Maris
Weinans, M. J.N.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
van Roosmalen, Jos J.M.
Netherlands, Leiden
A z Leiden
van der Slikke, J. W.
Netherlands, Zaandam
Ziekenhuis de Heel, Zaandam
Van Geijn, Herman P.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Pernet, Paula J.M.
Netherlands, Haarlem
Kennemer Hospital
Wolf, H.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Stigter, Robert H.
Netherlands, Utrecht
A z Utrecht
Wilczynski, J.
Poland, Lodz
Instytut Centrum Zdrowia Matki Polki
Vasco, E.
Portugal, Coimbra
Centro Hospitalar e Universitário de Coimbra
Abdullah, M.
Saudi Arabia, Riyadh
Security Forces Hospital Program Riyadh
Novak-Antolic, Z.
Slovenia, Ljubljana
Educational Research Institute Ljubljana
Danielian, P.
Unknown Affiliation
Jenkinson, S. D.
Italy
Redditch
Welch, C. R.
Unknown Affiliation
Griffin, C.
United Kingdom, Birmingham
Birmingham Heartlands
Gee, Harold
United Kingdom, Birmingham
Birmingham Hospital for Women
Tuffnell, Derek J.
United Kingdom, Bradford
Bradford Royal Infirmary
Cresswell, Janet L.
Unknown Affiliation
Tariq, T.
Unknown Affiliation
Sengupta, B.
Unknown Affiliation
Tydeman, G.
United Kingdom, Kirkcaldy
Forth Park
Churchill, David N.
United Kingdom, Sutton
Northallerton
Bewley, S.
United Kingdom, London
St Thomas’ Hospital
Fusi, L.
United Kingdom, London
Hammersmith
Lindow, Stephen W.
Unknown Affiliation
Johal, W.
Unknown Affiliation
Fairlie, Fiona
United Kingdom, Sheffield
Jessop Hospital
Neales, K.
Unknown Affiliation
Mason, G.
United Kingdom, Leeds
Leeds General Hospital
Scudamore, I.
United Kingdom, Leicester
Leicester College
Konje, Justin Chi
United Kingdom, Leicester
Leicester Roy al Infirmary
Walkinshaw, Stephen A.
United Kingdom, Liverpool
Liverpool
Griffiths, M.
United Kingdom, Luton
Luton and Dunstable General Hospital
Dawson, A.
Unknown Affiliation
Mires, G.
United Kingdom, Dundee
Ninewells Hospital
Johanson, Richard Brian
United Kingdom, Staffordshire
North Staffordshire Maternity
Fraser, Rupsha
United Kingdom, Sheffield
Northern General
Ibbs, P. Hendy
Unknown Affiliation
Steel, S. A.
United Kingdom, Peterborough
Peterborough Hospital
Ramsay, M.
United Kingdom, Nottingham
Queen's Medical Centre
Robins, J. B.
Unknown Affiliation
Heard, M. J.
Unknown Affiliation
Tonge, H. M.
Unknown Affiliation
Manyonda, I. T.
United Kingdom, London
St George's
Walker, J.
United Kingdom, Leeds
St James's University
Maresh, M.
United Kingdom, Manchester
St Mary's Hospital
Yoong, A.
United Kingdom, Isle of Wight
St Mary’s Hospital
Soothill, Peter W.
United Kingdom, Bristol
St Michaels Hospital University of Bristol
Cameron, Helen Mc D.
Unknown Affiliation
Byrne, D.
United Kingdom, Truro
The Royal Cornwall
Beattie, B.
United Kingdom, Cardiff
Cardiff
Bober, S.
United Kingdom
West Cumberland
Van Damme, M.
Unknown Affiliation
Kyriakides, S.
Unknown Affiliation
Pokorna, P.
Unknown Affiliation
Zimmerman, A.
Unknown Affiliation
Tsitsikas, H.
Unknown Affiliation
Mani, E.
Italy
Hungary—j Zsadanyiitaly—irccs Medea
Bosisio, P.
Italy
Hungary—j Zsadanyiitaly—irccs Medea
Mastritta, E.
Italy
Hungary—j Zsadanyiitaly—irccs Medea
Nicocia, M.
Italy
Hungary—j Zsadanyiitaly—irccs Medea
Fabris, C.
Italy
Hungary—j Zsadanyiitaly—irccs Medea
Eken, P.
Netherlands
Netherlands—c Koopman
De Vries, L.
Netherlands
Netherlands—c Koopman
Kubicka, Z.
Poland
Poland—a Prochowska
Ramalho, R.
Unknown Affiliation
Rashid, M.
Unknown Affiliation
Cerar-Kornhauser, L.
Unknown Affiliation
Thomas, Suzanne
Unknown Affiliation
Elliman, A.
Unknown Affiliation
Sim, T.
Unknown Affiliation
Swaminathan, S.
Unknown Affiliation
Walker, L.
Unknown Affiliation
McCormick, D.
Unknown Affiliation
Sibanda, Z.
Unknown Affiliation
Hughes, J.
Unknown Affiliation
Kilding, J.
Unknown Affiliation
O'Hara, A.
Unknown Affiliation
Harpin, V.
Unknown Affiliation
Statistics
Citations: 100
Authors: 100
Affiliations: 60
Identifiers
Doi:
10.1002/uog.20354
ISSN:
09607692
e-ISSN:
14690705
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Female