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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Vitamin D and reduced risk of breast cancer: A population-based case-control study
Cancer Epidemiology Biomarkers and Prevention, Volume 16, No. 3, Year 2007
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Description
Background: Vitamin D, antiproliferative and proapoptotic in breast cancer cell lines, can reduce the development of mammary tumors in carcinogen-exposed rats. Current evidence in humans is limited with some suggestion that vitamin D-related factors may reduce the risk of breast cancer. We conducted a population-based case-control study to assess the evidence for a relationship between sources of vitamin D and breast cancer risk. Methods: Women with newly diagnosed invasive breast cancer were identified from the Ontario Cancer Registry. Women without breast cancer were identified through randomly selected residential telephone numbers. Telephone interviews were completed for 972 cases and 1,135 controls. Odds ratios (OR) and 95% confidence intervals (CI) for vitamin D-related variables were estimated using unconditional logistic regression with adjustment for potential confounders. Results: Reduced breast cancer risks were associated with increasing sun exposure from ages 10 to 19 (e.g., OR, 0.65; 95% CI, 0.50-0.85 for the highest quartile of outdoor activities versus the lowest; P for trend = 0.0006). Reduced risk was also associated with cod liver oil use (OR, 0.76; 95% CI, 0.62-0.92) and increasing milk consumption (OR, 0.62 95% CI 0.45-0.86 for ≥10 glasses per week versus none; P for trend = 0.0004). There was weaker evidence for associations from ages 20 to 29 and no evidence for ages 45 to 54. Conclusion: We found strong evidence to support the hypothesis that vitamin D could help prevent breast cancer. However, our results suggest that exposure earlier in life, particularly during breast development, maybe most relevant. These results should be confirmed. Copyright © 2007 American Association for Cancer Research.
Authors & Co-Authors
Knight, Julia A.
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Lesosky, Maia R.
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Raboud, Janet M. M.
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Vieth, Reinhold
Canada, Toronto
Mount Sinai Hospital of University of Toronto
Statistics
Citations: 178
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1158/1055-9965.EPI-06-0865
ISSN:
10559965
Research Areas
Cancer
Study Design
Cross Sectional Study
Case-Control Study
Participants Gender
Female