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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prevalence and risk factors for cervical squamous intraepithelial lesions among women infected with HIV-1 in Makurdi, Nigeria
International Journal of Women's Health, Volume 4, No. 1, Year 2012
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Description
Background: The purpose of this study was to determine the prevalence and risk factors for cervical squamous intraepithelial lesions (SIL) among women infected with human immunodeficiency virus type 1 (HIV-1) receiving care at the Federal Medical Center Makurdi, Nigeria. Methods: Between March and December 2009, a total of 253 women infected with HIV-1 had cervical smears taken for cytology. HIV-1 RNA viral load and CD4 counts were also measured. Results: Of the 253 women, cervical SIL were present in 45 (17.8%). However, abnormal cervical cytology was noted in 146 (57.7%). Of those with abnormal cervical cytology, 101 (39.9%) women had atypical squamous cells of undetermined significance, 16 (6.3%) had low-grade SIL, and 29 (11.5%) women had high-grade SIL. The median CD4 lymphocyte count was lower in participants with cervical SIL compared with those without (132 versus 184 cells/mm 3; P = 0.03). The median HIV-1 RNA viral load was higher in women with cervical SIL (102,705 versus 64,391 copies/mL; P = 0.02). A CD4 lymphocyte count of <200 cells/mm 3 and an HIV-1 RNA viral load of <10,000 copies/mL were found to be significantly associated with cervical SIL. Conclusion: A high prevalence of cervical SIL was found among HIV-1-infected women in Makurdi, Nigeria. Increased immune suppression and HIV-1 viremia are significantly associated with cervical SIL. © 2012 Swende et al, publisher and licensee Dove Medical Press Ltd.
Authors & Co-Authors
Swende, Terrumun Z.
Nigeria, Makurdi
Benue State University
Ngwan, Stephen D.
Unknown Affiliation
Swende, Laadi T.
Nigeria, Makurdi
Federal Medical Centre Makurdi
Statistics
Citations: 17
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.2147/IJWH.S21205
e-ISSN:
11791411
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Nigeria
Participants Gender
Female