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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Genetic structure and phylogeography of Aedes aegypti, the dengue and yellow-fever mosquito vector in Bolivia
Infection, Genetics and Evolution, Volume 12, No. 6, Year 2012
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Description
Between the 16th and 18th centuries, . Aedes aegypti (Diptera: Culicidae), a mosquito native to Africa, invaded the Americas, where it was successively responsible for the emergence of yellow fever (YF) and dengue (DEN). The species was eradicated from numerous American countries in the mid-20th century, but re-invaded them in the 1970s and 1980s. Little is known about the precise identities of . Ae. aegypti populations which successively thrived in South America, or their relation with the epidemiological changes in patterns of YF and DEN. We examined these questions in Bolivia, where . Ae. aegypti, eradicated in 1943, re-appeared in the 1980s.We assessed the genetic variability and population genetics of Ae. aegypti samples in order to deduce their genetic structure and likely geographic origin. Using a 21-population set covering Bolivia, we analyzed the polymorphism at nine microsatellite loci and in two mitochondrial DNA regions (COI and ND4). Microsatellite markers revealed a significant genetic structure among geographic populations (FST=0.0627, P<0.0001) in relation with the recent re-expansion of Ae. aegypti in Bolivia. Analysis of mtDNA sequences revealed the existence of two genetic lineages, one dominant lineage recovered throughout Bolivia, and the second restricted to rural localities in South Bolivia. Phylogenic analysis indicated that this minority lineage was related to West African Ae. aegypti specimens. In conclusion, our results suggested a temporal succession of Ae. aegypti populations in Bolivia, that potentially impacted the epidemiology of dengue and yellow fever. © 2012 Elsevier B.V..
Authors & Co-Authors
Paupy, Christophe
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Le Goff, Gilbert
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Bolivia, Santa Cruz de la Sierra
Centro Nacional de Enfermedades Tropicales Cenetrop
Brengues, Cécile
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Guerra, Mabel
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Bolivia, Santa Cruz de la Sierra
Centro Nacional de Enfermedades Tropicales Cenetrop
Revollo, Jimmy
Bolivia, Santa Cruz de la Sierra
Centro Nacional de Enfermedades Tropicales Cenetrop
Barja Simon, Zaïra
Bolivia, Santa Cruz de la Sierra
Centro Nacional de Enfermedades Tropicales Cenetrop
Hervé, Jean Pierre
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Bolivia, Santa Cruz de la Sierra
Centro Nacional de Enfermedades Tropicales Cenetrop
Fontenille, Didier
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Statistics
Citations: 70
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.meegid.2012.04.012
ISSN:
15671348
e-ISSN:
15677257
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study