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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effects of graded mechanical compression of rabbit sciatic nerve on nerve blood flow and electrophysiological properties
Journal of Clinical Neuroscience, Volume 17, No. 4, Year 2010
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Description
Entrapment neuropathy is a frequent clinical problem that can be caused by, among other factors, mechanical compression; however, exactly how a compressive force affects the peripheral nerves remains poorly understood. In this study, using a rabbit model of sciatic nerve injury (n = 12), we evaluated the time-course of changes in intraneural blood flow, compound nerve action potentials, and functioning of the blood-nerve barrier during graded mechanical compression. Nerve injury was applied using a compressor equipped with a custom-made pressure transducer. Cessation of intraneural blood flow was noted at a mean compressive force of 0.457 ± 0.022 N (±SEM), and the compound action potential became zero at 0.486 ± 0.031 N. Marked extravasation of Evans blue albumin was noted after 20 min of intraneural ischemia. The functional changes induced by compression are likely due to intraneural edema, which could subsequently result in impairment of nerve function. These changes may be critical factors in the development of symptoms associated with nerve compression. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Yayama, Takafumi
Japan, Eiheiji
University of Fukui School of Medical Sciences
Kobayashi, Shigeru
Japan, Eiheiji
University of Fukui School of Medical Sciences
Uchida, Kenzou
Japan, Eiheiji
University of Fukui School of Medical Sciences
Kokubo, Yasuro
Japan, Eiheiji
University of Fukui School of Medical Sciences
Miyazaki, Tsuyoshi
Japan, Eiheiji
University of Fukui School of Medical Sciences
Takeno, Kenichi
Japan, Eiheiji
University of Fukui School of Medical Sciences
Mwaka, Erisa Sabakaki
Japan, Eiheiji
University of Fukui School of Medical Sciences
Baba, Hisatoshi
Japan, Eiheiji
University of Fukui School of Medical Sciences
Statistics
Citations: 33
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.jocn.2009.07.110
ISSN:
09675868
Research Areas
Violence And Injury