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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Malignancies among children and young people with HIV in Western and Eastern Europe and Thailand the European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) study group
AIDS, Volume 35, No. 12, Year 2021
Notification
URL copied to clipboard!
Description
Objectives: Investigate trends over time and predictors of malignancies among children and young people with HIV. Design: Pooled data from 17 cohorts in 15 countries across Europe and Thailand. Methods: Individuals diagnosed with HIV and presenting to paediatric care less than 18 years of age were included. Time at risk began at birth for children with documented vertically acquired HIV, and from first HIV-care visit for others. Children were followed until death, loss-to-follow-up, or last visit in paediatric or adult care (where data after transfer to adult care were available). Rates of reported malignancies were calculated overall and for AIDS-defining malignancies (ADM) and non-AIDS-defining malignancies (NADM) separately. Risk factors for any malignancy were explored using Poisson regression, and for mortality following a malignancy diagnosis using Cox regression. Results: Among 9632 individuals included, 140 (1.5%) were ever diagnosed with a malignancy, of which 112 (80%) were ADM. Overall, the rate of any malignancy was 1.18 per 1000 person-years; the rate of ADM decreased over time whereas the rate of NADM increased. Male sex, being from a European cohort, vertically acquired HIV, current severe immunosuppression, current viral load greater than 400 copies/ml, older age, and, for those not on treatment, earlier calendar year, were risk factors for a malignancy diagnosis. Fifty-eight (41%) individuals with a malignancy died, a median 2.4 months (IQR 0.6-8.8) after malignancy diagnosis. Conclusion: The rate of ADM has declined since widespread availability of combination ART, although of NADM, there was a small increase. Mortality following a malignancy was high, warranting further investigation. © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8462452/bin/aids-35-1973-s001.docx
Authors & Co-Authors
Chappell, Elizabeth
Unknown Affiliation
Turkova, Anna
Unknown Affiliation
Goetghebuer, Tessa
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Chiappini, Elena
Unknown Affiliation
Galli, Luisa
Unknown Affiliation
Judd, Ali M.
Unknown Affiliation
Spoulou, Vana I.
Unknown Affiliation
Marczyńska, Magdalena
Poland, Warsaw
Medical University of Warsaw
Poland, Warsaw
Sp Zoz Wojewódzki Szpital Zakazny - Centrum Diagnostyki I Terapii Aids, Warszawa
Ene, Luminiţa
Unknown Affiliation
Voronin, Evgeny E.
Russian Federation, Moscow
Ministry of Health of Russian Federation
Jourdain, Gonzague
Unknown Affiliation
Ngo-Giang-Huong, Nicole
Unknown Affiliation
Fortuny, Clàudia
Unknown Affiliation
Navarro, Marisa Luisa
Unknown Affiliation
Ramos, José Tomás
Unknown Affiliation
Navèr, Lars
Sweden, Stockholm
Karolinska Universitetssjukhuset
Bailey, Heather
Unknown Affiliation
Malyuta, Ruslan
Unknown Affiliation
Volokha, Alla P.
Unknown Affiliation
Bamford, A. R.J.
Unknown Affiliation
Crichton, Siobhan L.
Unknown Affiliation
Foster, Caroline J.
Unknown Affiliation
Thorne, Claire N.
Unknown Affiliation
Collins, I. J.
Unknown Affiliation
Giaquinto, Carlo
Unknown Affiliation
Gibb, Diana M.
Unknown Affiliation
Duff, Charlotte
Unknown Affiliation
Goodall, Ruth L.
Unknown Affiliation
Lundin, Rebecca
Unknown Affiliation
Milanzi, Edith B.
Unknown Affiliation
Nardone, Alessandra
Unknown Affiliation
Hainaut, Marc
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Delforge, Marc D.
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Tovo, P.
Unknown Affiliation
Miniaci, Angela
Unknown Affiliation
Badolato, Raffaele
Unknown Affiliation
Montagnani, Carlotta
Unknown Affiliation
Di Biagio, Antonio
Unknown Affiliation
Grignolo, Sara
Unknown Affiliation
Giacomet, Vania
Unknown Affiliation
Cellini, Monica
Unknown Affiliation
Donà, Daniele
Unknown Affiliation
Esposito, Susanna Maria Roberta
Unknown Affiliation
Zuccaro, Valentina
Unknown Affiliation
Consolini, Rita
Unknown Affiliation
Bernardi, Stefania
Unknown Affiliation
Mazza, Antonio
Unknown Affiliation
Garazzino, Silvia
Unknown Affiliation
Pajkrt, Dasja
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Jurriaans, Suzanne
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Back, Nicole K.T.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Zaaijer, Hans L.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Berkhout, Ben
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Cornelissen, Marion T.E.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Wolthers, Katja C.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Fraaij, Pieter L.A.
Netherlands, Rotterdam
Erasmus Mc Sophia Children’s Hospital
Vermont, Clementien L.
Netherlands, Rotterdam
Erasmus Mc Sophia Children’s Hospital
Boucher, Charles A.B.
Netherlands, Rotterdam
Erasmus Mc Sophia Children’s Hospital
Koopmans, Marion P.G.
Netherlands, Rotterdam
Erasmus Mc Sophia Children’s Hospital
Pas, Suzan D.
Netherlands, Rotterdam
Erasmus Mc Sophia Children’s Hospital
van Aerde, Koen J.
Netherlands, Nijmegen
Radboud University Medical Center
Rahamat-Langendoen, Janette C.
Netherlands, Nijmegen
Radboud University Medical Center
Stelma, Foekje F.
Netherlands, Nijmegen
Radboud University Medical Center
Schölvinck, Elisabeth H.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Bont, Louis J.
Netherlands, Utrecht
University Medical Center Utrecht
Geelen, Sibyl P.M.
Netherlands, Utrecht
University Medical Center Utrecht
Wolfs, Tom F.W.
Netherlands, Utrecht
University Medical Center Utrecht
Schuurman, Rob J.
Netherlands, Utrecht
University Medical Center Utrecht
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Reiss, Peter
Unknown Affiliation
Bezemer, Daniela O.
Unknown Affiliation
Smit, Colette
Unknown Affiliation
Wit, Ferdinand W.N.M.
Unknown Affiliation
Hillebregt, Mariska M.J.
Unknown Affiliation
de Groot, Laura
Unknown Affiliation
Popielska, Jolanta
Poland, Warsaw
Medical University of Warsaw
Poland, Warsaw
Sp Zoz Wojewódzki Szpital Zakazny - Centrum Diagnostyki I Terapii Aids, Warszawa
Soler-Palacín, P.
Spain, Barcelona
Hospital Universitari Vall D'hebron
Pérez-Hoyos, Santiago
Spain, Barcelona
Hospital Universitari Vall D'hebron
Mur-Sierra, Antonío
Spain, Barcelona
Hospital Del Mar
Noguera-Julián, Antoni Diez
Spain, Esplugues de Llobregat
Hospital Sant Joan de Déu Barcelona
Mellado-Peña, María José
Unknown Affiliation
González Tomé, María Isabel
Spain, Madrid
Hospital Universitario 12 de Octubre
Rojo, Pablo
Spain, Madrid
Hospital Universitario 12 de Octubre
Blázquez-Gamero, Daniel
Spain, Madrid
Hospital Universitario 12 de Octubre
Prieto, Luis M.
Spain, Getafe
Hospital Universitario de Getafe
Guillén Martín, Sara
Spain, Getafe
Hospital Universitario de Getafe
Saavedra, Jesús
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Muñoz, María Ángeles
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Badillo-Navarro, Katie
Spain, Madrid
Hospital Universitario de Torrejón
Colino-Gil, María Elena
Spain, Las Palmas de Gran Canaria
Complejo Hospitalario Universitario Insular Materno-infantil
Santos, Juan Luis
Spain, Granada
Complejo Hospitalario Universitario de Granada
Pérez C, Carlos M.
Spain, Gijon
Hospital de Cabuenes
Ochoa Sangrador, Carlos
Unknown Affiliation
Soeria-Atmadja, Sandra
Sweden, Stockholm
Karolinska Universitetssjukhuset
Belfrage, Erik
Sweden, Stockholm
Karolinska Universitetssjukhuset
Aebi-Popp, Karoline
Unknown Affiliation
Anagnostopoulos, Alexia
Unknown Affiliation
Battegay, Manuel
Unknown Affiliation
Bernasconi, Enos
Unknown Affiliation
Böni, Jürg
Unknown Affiliation
Braun, Dominique Laurent
Unknown Affiliation
Bucher, Heíner C.C.
Unknown Affiliation
Cavassini, Matthias
Unknown Affiliation
Ciuffi, Angela
Unknown Affiliation
Duppenthaler, Andrea
Unknown Affiliation
Dollenmaier, Guenter
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Elzi, Luigia
Unknown Affiliation
Fehr, Jan Sven
Unknown Affiliation
Fellay, Jacques
Unknown Affiliation
Furrer, Hansjakob Jackob
Unknown Affiliation
Fux, Christoph Andreas
Unknown Affiliation
Günthard, Huldrych F.
Unknown Affiliation
Haerry, David Hans Ulrich
Unknown Affiliation
Hasse, Barbara Katharina
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Huber, Michael J.
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Keiser, Olivia
Unknown Affiliation
Klimkait, Thomas
Unknown Affiliation
Kouyos, Roger D.
Unknown Affiliation
Kovari, Helen
Unknown Affiliation
Ledergerber, Bruno
Unknown Affiliation
Martinetti, Gladys
Unknown Affiliation
Martínez de Tejada, Begoῆa
Unknown Affiliation
Marzolini, Catia
Unknown Affiliation
Metzner, K. J.
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Paioni, Paolo
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Perreau, Matthieu
Unknown Affiliation
Rauch, Andri
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Scherrer, Alexandra U.
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Tarr, Philip E.
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Vernazza, Pietro Luigi
Unknown Affiliation
Weber, Rainer
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Hansudewechakul, Rawiwan
Thailand, Chiangmai
Chiangrai Prachanukroh Hospital
Ngampiyaskul, Chaiwat
Unknown Affiliation
Kanjanavanit, Suparat
Unknown Affiliation
Layangool, Prapaisri
Unknown Affiliation
Na-Rajsima, Sathaporn
Unknown Affiliation
Than-In-At, Kanchana
Unknown Affiliation
Lyall, Hermione
United Kingdom, London
Mrc Clinical Trials Unit
Butler, Karina M.
United Kingdom, London
Mrc Clinical Trials Unit
Doerholt, Katja
United Kingdom, London
Mrc Clinical Trials Unit
Kenny, Julia M.
United Kingdom, London
Mrc Clinical Trials Unit
Klein, Nigel J.
United Kingdom, London
Mrc Clinical Trials Unit
McMaster, Paddy
United Kingdom, London
Mrc Clinical Trials Unit
Riordan, Andrew F.
United Kingdom, London
Mrc Clinical Trials Unit
Shingadia, Delane V.
United Kingdom, London
Mrc Clinical Trials Unit
Tudor-Williams, Gareth
United Kingdom, London
Mrc Clinical Trials Unit
Welch, Steven B.
United Kingdom, London
Mrc Clinical Trials Unit
Fairbrother, Keith
Unknown Affiliation
Le Prevost, Marthe Sophie Elise
Unknown Affiliation
Van-Looy, Nadine
Unknown Affiliation
Fidler, Katy J.
United Kingdom, Sussex
University Hospitals Sussex
Bernatoniene, Jolanta
United Kingdom, Bristol
University Hospitals Bristol and Weston Nhs Foundation Trust
Flynn, Jacquie
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Segal, Shelley
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Bandi, Srini
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Eisenhut, Michael
United Kingdom, Bedford
Bedfordshire Hospitals Nhs Foundation Trust
Flood, Terrence J.
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
Williams, Amanda J.
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Williams, Bhanu
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Clarke, Lynda
United Kingdom, Aberdeen
Royal Aberdeen Children's Hospital
Benson, Constance Ann
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Patel, Sanjay Valabh
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
Sharland, Mike R.
United Kingdom, London
St George's University Hospitals Nhs Foundation Trust
Evans, Jennifer A.
United Kingdom, Cardiff
University Hospital of Wales
Blake, Elizabeth
United Kingdom, Cardiff
University Hospital of Wales
Statistics
Citations: 2
Authors: 176
Affiliations: 93
Identifiers
Doi:
10.1097/QAD.0000000000002965
ISSN:
02699370
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Male