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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Laboratory selection for and characteristics of pyrethroid resistance in the malaria vector Anopheles funestus
Medical and Veterinary Entomology, Volume 19, No. 3, Year 2005
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Description
A laboratory colony of Anopheles funestus Giles (Diptera: Culicidae) was established in 2000 from material collected from southern Mozambique where pyrethroid resistance had been demonstrated in the wild population. A subsample of the colony was selected for pyrethroid resistance using 0.1% lambda-cyhalothrin. Bioassay susceptibility tests in subsequent generations F2 to F4 showed increased resistance with each successive generation. Survival of individual mosquitoes fed only on 10% sugar solution, increased with age up to 4 days, but by day 10 had decreased significantly. However, females that had been mated and given bloodmeals showed no such increase in mortality with age. Biochemical analysis of resistant and susceptible individuals showed increased monooxygenase and glutathione S-transferase activity but no significant correlation with age of the mosquitoes. © 2005 The Royal Entomological Society.
Authors & Co-Authors
Hunt, Richard H.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Brooke, Basil D.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Pillay, Candice
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Koekemoer, Lizette Leonie
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Coetzee, Maureen
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 202
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-2915.2005.00574.x
ISSN:
0269283X
e-ISSN:
13652915
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Mozambique
Participants Gender
Female