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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1
Cell, Volume 125, No. 6, Year 2006
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Description
High-level immune activation and T cell apoptosis represent a hallmark of HIV-1 infection that is absent from nonpathogenic SIV infections in natural primate hosts. The mechanisms causing these varying levels of immune activation are not understood. Here, we report that nef alleles from the great majority of primate lentiviruses, including HIV-2, downmodulate TCR-CD3 from infected T cells, thereby blocking their responsiveness to activation. In contrast, nef alleles from HIV-1 and a subset of closely related SIVs fail to downregulate TCR-CD3 and to inhibit cell death. Thus, Nef-mediated suppression of T cell activation is a fundamental property of primate lentiviruses that likely evolved to maintain viral persistence in the context of an intact host immune system. This function was lost during viral evolution in a lineage that gave rise to HIV-1 and may have predisposed the simian precursor of HIV-1 for greater pathogenicity in humans. © 2006 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Schindler, Michael
Germany, Ulm
Universität Ulm
Münch, Jan L.
Germany, Ulm
Universität Ulm
Kutsch, Olaf
United States, Birmingham
The University of Alabama at Birmingham
Li, Hui
United States, Birmingham
The University of Alabama at Birmingham
Santiago, Mario L.
United States, Birmingham
The University of Alabama at Birmingham
Bibollet-Ruche, Frédéric
United States, Birmingham
The University of Alabama at Birmingham
Müller-Trutwin, Michaela C.
France, Paris
Institut Pasteur, Paris
Novembre, Francis J.
United States, Atlanta
Emory University
Peeters, Martine F.
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Courgnaud, Valérie
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Bailes, Elizabeth
United Kingdom, Nottingham
University of Nottingham
Roques, Pierre A.
Gabon
Cirmf
Sodora, Donald L.
United States, Dallas
Ut Southwestern Medical Center
Silvestri, Guido Do
United States, Atlanta
Emory University
United States, Philadelphia
University of Pennsylvania
Sharp, Paul M.
United Kingdom, Nottingham
University of Nottingham
Hahn, Beatrice H.
United States, Birmingham
The University of Alabama at Birmingham
Kirchhoff, Frank
Germany, Ulm
Universität Ulm
Statistics
Citations: 418
Authors: 17
Affiliations: 9
Identifiers
Doi:
10.1016/j.cell.2006.04.033
ISSN:
00928674
Research Areas
Cancer
Infectious Diseases