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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Ngoye virus: A novel evolutionary lineage within the genus Flavivirus
Journal of General Virology, Volume 87, No. 11, Year 2006
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Description
By using degenerate primers deduced from conserved patterns in the flavivirus polymerase gene, a novel RNA virus was discovered in Rhipicephalus ticks sampled from members of the family Bovidae in Senegal. It was named Ngoye virus (NGOV) after the location from which it was isolated. Viral particles could be observed by electron microscopy, but isolation in vertebrate or invertebrate cell lines or by intracerebral infection of newborn mice remained unsuccessful. This is atypical of recognized arboviruses. The characterization of 4176 nt of the non-structural genes revealed that NGOV is a novel flavivirus species. It forms a distinct phylogenetic lineage related distantly to previously identified members of the genus Flavivirus. Analysis of genetic data suggested that the processing of the NGOV polyprotein and the organization of its replication complex are similar to those of flaviviruses. Together with other recent data, these findings suggest that a large number of viruses related distantly to 'classical' arthropod-borne flaviviruses remain to be discovered. © 2006 SGM.
Authors & Co-Authors
Grard, Gilda
France, Marseille
Hopital la Timone
Lemasson, Jean Jacques
France, Marseille
Hopital la Timone
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Sylla, Massamba
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Dubot, Audrey
Thailand, Nakhon Pathom
Mahidol University
Cook, Shelley
United Kingdom, Oxford
University of Oxford
Molez, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Pourrut, Xavier
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Charrel, Remi N.
France, Marseille
Hopital la Timone
Gonzalez, J. P.
Thailand, Nakhon Pathom
Mahidol University
Munderloh, Ulrike G.
United States, Minneapolis
University of Minnesota Twin Cities
Holmes, Edward C.
United States, University Park
Pennsylvania State University
De-Lamballerie, Xavier Nicolas
France, Marseille
Hopital la Timone
Statistics
Citations: 12
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1099/vir.0.82071-0
ISSN:
00221317
Research Areas
Genetics And Genomics
Study Locations
Senegal