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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Higher leptin levels in Asian Indians than Creoles and Europids: A potential explanation for increased metabolic risk
International Journal of Obesity, Volume 34, No. 5, Year 2010
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Description
Background and purpose:Leptin predicts cardiovascular diseases and type 2 diabetes, diseases to which Asian Indians are highly susceptible. As a risk marker, leptin's intra-individual and seasonal stability is unstudied and only small studies have compared leptin levels in Asian Indians with other populations. The aim of this study was to explore ethnicity related differences in leptin levels and its intra-individual and seasonal stability.Methods:Leptin and anthropometric data from the northern Sweden MONICA (3513 Europids) and the Mauritius Non-communicable Disease (2480 Asian Indians and Creoles) studies were used. In both studies men and women, 25-to 74-year old, participated in both an initial population survey and a follow-up after 5-13 years. For the analysis of seasonal leptin variation, a subset of 1780 participants, 30-to 60-year old, in the Västerbotten Intervention Project was used.Results:Asian Indian men and women had higher levels of leptin, leptin per body mass index (BMI) unit (leptin/BMI) or per cm in waist circumference (WC; leptin/waist) than Creoles and Europids when adjusted for BMI (all P<0.0005) or WC (all P<0.005). In men, Creoles had higher leptin, leptin/BMI and leptin/waist than Europids when adjusted for BMI or WC (all P<0.0005). In women, Creoles had higher leptin/BMI and leptin/waist than Europids only when adjusted for WC (P<0.0005). Asian Indian ethnicity in both sexes, and Creole ethnicity in men, was independently associated with high leptin levels. The intra-class correlation for leptin was similar (0.6-0.7), independently of sex, ethnicity or follow-up time. No seasonal variation in leptin levels was seen.Conclusion: Asian Indians have higher levels of leptin, leptin/BMI and leptin/waist than Creoles and Europids. Leptin has a high intra-individual stability and seasonal leptin variation does not appear to explain the ethnic differences observed here. © 2010 Macmillan Publishers Limited All rights reserved.
Authors & Co-Authors
Lilja, M.
Sweden, Ostersund
Jämtland County Council
Sweden, Umea
Umeå Universitet
Rolandsson, Olov
Sweden, Umea
Umeå Universitet
Shaw, Jonathan E.
Australia, Melbourne
Baker Heart and Diabetes Institute
Pauvaday, Vassen K.
Mauritius, Port Louis
Ministry of Health and Quality of Life
Cameron, Adrian J.
Australia, Melbourne
Baker Heart and Diabetes Institute
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Helsingin Yliopisto
Finland, Seinajoki
South Ostrobothnia Central Hospital
Alberti, K. George M.M.
United Kingdom, London
Imperial College London
Zimmet, Paul Z.
Australia, Melbourne
Baker Heart and Diabetes Institute
Söderberg, Stefan
Sweden, Umea
Umeå Universitet
Australia, Melbourne
Baker Heart and Diabetes Institute
Statistics
Citations: 39
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1038/ijo.2010.19
ISSN:
03070565
e-ISSN:
14765497
Research Areas
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Mauritius
Participants Gender
Male
Female