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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Initiation of humoral immunity. II. The effects of T-independent and T-dependent antigens on the distribution of lymphocyte populations
Developmental and Comparative Immunology, Volume 26, No. 8, Year 2002
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Description
The effect of injecting T-independent (lipopolysaccharide, LPS) and T-dependent (bovine serum albumin, BSA) antigens on the redistribution of lymphocyte populations in immature male chickens was investigated. In the blood, percentages of total T-cells (CD3+), T-helper cells (CD4+), and T-cytotoxic/suppressor cells (CD8+) significantly decreased post-LPS injection (PLI) but not post-BSA injection (PBI), while percentages of monocytes/thrombocytes (K1+) significantly increased PLI. Interleukin-1 receptor expression on blood lymphocytes increased significantly PLI and PBI. In the spleen, the percentages of total T-cells (CD3+) increased significantly PLI and PBI, macrophage (K1+) percentages increased significantly PLI, while B-cell percentages decreased significantly PLI. These results indicate that following antigen injection, there is a redistribution of peripheral blood lymphocytes (specifically T-lymphocytes) to secondary lymphoid organs and the kinetics and magnitude of the changes can differ according to the type of antigen used. © 2002 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Gehad, Ahmed E.
Egypt, Giza
National Research Centre
Lillehoj, Hyun S.
United States, Washington, D.c.
Usda Agricultural Research Service
Hendricks, Gilbert L.
United States, University Park
Pennsylvania State University
Mashaly, Magdi M.
United States, University Park
Pennsylvania State University
Statistics
Citations: 15
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/S0145-305X(02)00021-6
ISSN:
0145305X
Participants Gender
Male