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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evaluation of saliva as an alternative matrix for monitoring plasma Zidovudine, Lamivudine and Nevirapine concentrations in Rwanda
Current HIV Research, Volume 9, No. 4, Year 2011
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Description
Saliva may provide interesting advantages as matrix for compliance measurements, pharmacokinetic studies and therapeutic drug monitoring in resource limited countries. We investigated the feasibility of using saliva for compliance monitoring of zidovudine (ZDV), lamivudine (3TC) and nevirapine (NVP) in 29 HIV-1 infected patients from Rwanda. ZDV, 3TC and NVP drug levels were quantified by an LC/MS-MS method in plasma and stimulated saliva samples and compared using Bland-Altman analysis. Seven patients demonstrated undetectable saliva ZDV levels while five out of these seven also showed no 3TC salivary concentrations. For the other samples, we observed a good agreement between salivary and plasma concentrations of each antiretroviral drug. A significant relation between the difference in saliva and plasma ZDV concentrations and the average ZDV concentration in the two matrices was deduced as follows: y = -380.15 + 1.79 x. The log saliva and plasma concentration difference of both 3TC and NVP was consistent across the range of average log concentration. Overall, we showed large agreement limits suggesting a wide inter patient variability that may result in non-reliable plasma level predictions from saliva drug measurements. Therefore, our results indicate that saliva may serve as a valuable tool only for NVP compliance testing because of its high salivary concentration. © 2011 Bentham Science Publishers Ltd.
Authors & Co-Authors
Gras, Alain
Luxembourg, Strassen
Luxembourg Institute of Health
Schneider, Serge
Luxembourg, Luxembourg
Santé Laboratoire National de Santé
Karasi, Jean Claude
Luxembourg, Strassen
Luxembourg Institute of Health
Ternes, Anne Marie
Luxembourg, Strassen
Luxembourg Institute of Health
Sauvageot, Nicolas
Luxembourg, Strassen
Luxembourg Institute of Health
Karasi-Omes, Christine
Luxembourg, Luxembourg
Lux-development
Henry, Anne Pascale
Rwanda, Kigali
Centre Hospitalier Universitaire de Kigali
Schmit, Jean Claude
Luxembourg, Strassen
Luxembourg Institute of Health
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Seguin-Devaux, Carole
Luxembourg, Strassen
Luxembourg Institute of Health
Arendt, Vic
Luxembourg, Strassen
Luxembourg Institute of Health
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Statistics
Citations: 10
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.2174/157016211796320270
ISSN:
1570162X
e-ISSN:
18734251
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Rwanda