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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Multiple independent emergences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria
Journal of Virology, Volume 87, No. 9, Year 2013
Notification
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Description
Since 2005, a large poliomyelitis outbreak associated with type 2 circulating vaccine-derived poliovirus (cVDPV2) has occurred in northern Nigeria, where immunization coverage with trivalent oral poliovirus vaccine (tOPV) has been low. Phylogenetic analysis of P1/capsid region sequences of isolates from each of the 403 cases reported in 2005 to 2011 resolved the outbreak into 23 independent type 2 vaccine-derived poliovirus (VDPV2) emergences, at least 7 of which established circulating lineage groups. Virus from one emergence (lineage group 2005-8; 361 isolates) was estimated to have circulated for over 6 years. The population of the major cVDPV2 lineage group expanded rapidly in early 2009, fell sharply after two tOPV rounds in mid-2009, and gradually expanded again through 2011. The two major determinants of attenuation of the Sabin 2 oral poliovirus vaccine strain (A481 in the 5=-untranslated region [5=-UTR] and VP1-Ile143) had been replaced in all VDPV2 isolates; most A481 5=-UTR replacements occurred by recombination with other enteroviruses. cVDPV2 isolates representing different lineage groups had biological properties indistinguishable from those of wild polioviruses, including efficient growth in neuron-derived HEK293 cells, the capacity to cause paralytic disease in both humans and PVR-Tg21 transgenic mice, loss of the temperature-sensitive phenotype, and the capacity for sustained person-to-person transmission. We estimate from the poliomyelitis case count and the paralytic case-to-infection ratio for type 2 wild poliovirus infections that~700,000 cVDPV2 infections have occurred during the outbreak. The detection of multiple concurrent cVDPV2 outbreaks in northern Nigeria highlights the risks of cVDPV emergence accompanying tOPV use at low rates of coverage in developing countries. © 2013, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3624331/bin/supp_87_9_4907__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3624331/bin/JVI.02954-12_zjv999097532so1.pdf
Authors & Co-Authors
Burns, Cara Carthel
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Shaw, Jing
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Jorba, Jaume C.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Bukbuk, David Nadeba
Nigeria, Maiduguri
University of Maiduguri
Adu, Festus Doyin
Nigeria, Ibadan
University of Ibadan
Gumede, Nicksy
South Africa, Johannesburg
National Institute for Communicable Diseases
Pate, Muhammad Ali
Nigeria, Abuja
National Primary Health Care Development Agency
Abanida, Emmanuel Ade
Nigeria, Abuja
National Primary Health Care Development Agency
Gasasira, Alex Ntale
Nigeria, Abuja
World Health Organization, Nigeria
Iber, Jane C.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Chen, Qi
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Vincent, Annelet
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Chenoweth, Paul J.
United States, Atlanta
Centers for Disease Control and Prevention
Henderson, Elizabeth
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Wannemuehler, Kathleen A.
United States, Atlanta
Centers for Disease Control and Prevention
Naeem, Asif
Japan, Tokyo
National Institute of Infectious Diseases
Umami, Rifqiyah Nur
Japan, Tokyo
National Institute of Infectious Diseases
Nishimura, Yorihiro
Japan, Tokyo
National Institute of Infectious Diseases
Shimizu, Hiroyuki
Japan, Tokyo
National Institute of Infectious Diseases
Baba, Maryceline Mandu
Nigeria, Maiduguri
University of Maiduguri
Adeniji, Johnson Adekunle
Nigeria, Ibadan
University of Ibadan
Williams, A. J.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Kilpatrick, David R.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Oberste, Mark Steven
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Wassilak, Steven G.Fite
United States, Atlanta
Centers for Disease Control and Prevention
Tomori, Oyewale
Nigeria, Ede
Redeemer‘s University
Pallansch, Mark A.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Kew, Olen M.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Statistics
Citations: 139
Authors: 28
Affiliations: 9
Identifiers
Doi:
10.1128/JVI.02954-12
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Nigeria