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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mixed human immunodeficiency virus (Hiv) infection in an individual: Demonstration of both hiv type 1 and type 2 proviral sequences by using polymerase chain reaction
Journal of Infectious Diseases, Volume 158, No. 6, Year 1988
Notification
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Description
Sera from persons seroreactive to both human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), by whole-virus (VEIA) enzyme immunoassays (EIAs) for each virus, were selected from a seroprevalence study of 944 persons in Abidjan, Cote d’Ivoire, West Africa, in 1987. These sera were subsequently tested for HIV-1 and HIV-2 antibody specificity by type-specific peptide EIAs (PEIA) and western blot (WB) analysis for both viruses. Peripheral blood monocytes (PBMCs) from representative individuals were cultured in the presence of phytohemagglutinin-stimulated normal donor PBMCs. These cultures were periodically monitored for HIV-1 and HIV-2 proviral sequences by using the selective DNA amplification technique polymerase chain reaction (PCR). As an outgrowth of this study, we report the case of a person dually reactive by various serological techniques in whom proviral sequences from HIV-1 and HIV-2 were detected by PCR. This is the first confirmed case of a mixed HIV-1 and HIV-2 infection in a single individual. © 1988 by The University of Chicago.
Authors & Co-Authors
Rayfield, Mark A.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
de Cock, Kevin M.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Heyward, William L.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Goldstein, Lynn
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Krebs, John W.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Kwok, Shirley Y.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Lee, Stephanie
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
McCormick, Joseph B.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Moreau, Jacques M.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Odéhouri, Koudou P.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Schochetman, Gerald C.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Sninsky, John J.
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Ou, Chin Yih
United States, Atlanta
National Center for Infectious Diseases
Cote D'ivoire, Abidjan
Projet Retro-cl
United States
Genetics Systems
Switzerland, Basel
Novartis International ag
Statistics
Citations: 161
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/158.6.1170
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries