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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth
Blood, Volume 115, No. 22, Year 2010
Notification
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Description
The high prevalence of hemoglobin S (HbS) in Africa and hemoglobin C (HbC) in parts of West Africa is caused by the strong protection against severe falciparum malaria during childhood. Much less is known about the effect of HbS and especially HbC on Plasmodium falciparum infection, uncomplicated malaria, and anemia. A total of 1070 children from the Ashanti Region, Ghana, were enrolled at the age of 3 months and visited monthly until 2 years of age. The effects of the β-globin genotype on the age-dependent incidence of malaria, levels of parasitemia, and hemoglobin as well as physical development were analyzed by population-averaged models. Infants with HbAS were protected from uncomplicated malaria (P < .005) and anemia (P < .001), had lower age-adjusted parasite densities (P < .001), and higher age-adjusted hemoglobin levels compared with children with the HbAA genotype (P = .004). In contrast, HbAC carriers had lower hemoglobin levels (P < .033) and were not protected against malaria or anemia. Notably, infants with HbAS were also significantly protected against stunting compared with carriers of HbAA or HbAC. This indicates differing mechanisms of protection against malaria of HbAS and HbAC and might help to understand why HbC is restricted to distinct areas of West Africa. © 2010 by The American Society of Hematology.
Authors & Co-Authors
Kreuels, Benno
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Germany, Hamburg
Section for Tropical Medicine
Kreuzberg, Christina
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Kobbe, Robin
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Ayim-Akonor, Matilda
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Apiah-Thompson, Peter
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Thompson, Benedicta
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Ehmen, Christa
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Adjei, Samuel
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Ghana, Accra
Ministry of Health Ghana
Langefeld, Iris
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Adjei, Ohene
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
May, Juergen ü.
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Statistics
Citations: 84
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1182/blood-2009-09-241844
ISSN:
00064971
Research Areas
Food Security
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Multi-countries
Ghana