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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chemotherapy of advanced esophageal carcinoma: Eastern cooperative oncology group experience
Cancer, Volume 46, No. 10, Year 1980
Notification
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Description
In a Phase II study, patients with measurable metastatic or recurrent esophageal carcinoma randomly received either Adriamycin (ADR), 60 mg/M2 I.V. q three weeks, or methotrexate (MTX), 40 mg/M2 I. V. q one week, or 5‐fluorouracil (5‐FU), 500 mg/M2 I.V. x 5 days q five weeks. Objective partial response rates for 72 patients were 5% for ADR (one of 20), 12% for MTX (three of 26), and 15% for 5‐FU (four of 26). There were no complete responses. Median duration of response was 13 weeks. Median survival was 14 weeks (eight weeks for ADR, 14 weeks for MTX, and 15 weeks for 5‐FU). Factors of liver metastasis, adjacent anatomic involvement, time from initial diagnosis to study entry, and prior radiation were found to be significant determinants of survival. Adriamycin did not appear to benefit patients with advanced measurable squamous cell carcinoma of the esophagus. Methotrexate and 5‐fluorouracil showed comparable activity and survival, although methotrexate was slightly more toxic. Copyright © 1980 American Cancer Society
Authors & Co-Authors
Ezdinli, Ediz Z.
United States, Chicago
Chicago Medical School
Gelber, Richard D.
United States, Boston
Dana-farber Cancer Institute
Desai, Dinesh V.
United States, Chicago
Chicago Medical School
Falkson, Geoffrey G.
South Africa, Pretoria
University of Pretoria
Moertel, Charles G.
United States, Rochester
Mayo Clinic
Hahn, Richard G.
United States, Rochester
Mayo Clinic
Statistics
Citations: 99
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1002/1097-0142(19801115)46:10<2149::AID-CNCR2820461006>3.0.CO;2-W
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Environmental