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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Characterization of urinary biomarkers of hepatocellular carcinoma using magnetic resonance spectroscopy in a Nigerian population
Journal of Proteome Research, Volume 9, No. 2, Year 2010
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Description
Hepatocellular carcinoma (HCC) is the commonest primary hepatic malignancy worldwide. Current serum diagnostic biomarkers, such as α-fetoprotein, are expensive and insensitive in early tumor diagnosis. Urinary biomarkers differentiating HCC from chronic liver disease would be practical and widely applicable. Using an 11.7T nuclear magnetic resonance system, urine was analyzed from three well-matched subject groups, collected at Jos University Teaching Hospital (JUTH), Nigeria. Multivariate factor analyses were performed using principal components analysis (PCA) and partial least-squares discriminant analysis (PLS-DA). All patients were of Nigerian descent: 18 hepatitis B surface antigen (HBsAg)-positive patients with HCC, 10 HBsAg positive patients with cirrhosis, and 15 HBsAg negative healthy Nigerian controls. HCC patients were distinguished from healthy controls, and from the cirrhosis cohort, with sensitivity/specificity of 100%/93% and 89.5%/88.9%, respectively. Metabolites that most strongly contributed to the multivariate models were creatinine, carnitine, creatine and acetone. Urinary 1H MRS with multivariate statistical analysis was able to differentiate patients with HCC from normal subjects and patients with cirrhosis. Creatinine, carnitine, creatine and acetone were identified as the most influential metabolites. These findings have identified candidate urinary HCC biomarkers which have potential to be developed as simple urinary screening tests for the clinic. © 2010 American Chemical Society.
Authors & Co-Authors
Shariff, Mohamed I.F.
United Kingdom, London
Imperial College London
Ladep, Nimzing G.
Nigeria, Jos
University of Jos
Cox, I. Jane
United Kingdom, London
Imperial College London
Williams, Horace R.T.
United Kingdom, London
Imperial College London
Okeke, Edith Nonyelum
Nigeria, Jos
University of Jos
Malu, Abraham O.
Unknown Affiliation
Thillainayagam, Andrew V.
United Kingdom, London
Imperial College London
Crossey, Mary M.E.
United Kingdom, London
Imperial College London
Khan, Shahid A.
United Kingdom, London
Imperial College London
Thomas, Howard C.
United Kingdom, London
Imperial College London
Taylor-Robinson, Simon David
United Kingdom, London
Imperial College London
Statistics
Citations: 80
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1021/pr901058t
ISSN:
15353893
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Nigeria