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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study
Movement Disorders, Year 2023
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Description
Background: Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated. Objective: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group. Methods: Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated. Results: Overall, people with PD had a regionally smaller posterior lobe (dmax = −0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (dmax = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (dmax = −0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = −0.17). Conclusions: We provide evidence of a dissociation between anterior “motor” lobe and posterior “non-motor” lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors & Co-Authors
Laansma, Max A.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Neuroscience
Assogna, Francesca
Italy, Rome
Irccs Fondazione Santa Lucia
Berendse, Henk W.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Carr, Jonathan A.
South Africa, Stellenbosch
Stellenbosch University
Cendes, Fernando
Brazil, Campinas
Universidade Estadual de Campinas
Dalrymple-Alford, J. C.
New Zealand, Christchurch
New Zealand Brain Research Institute
New Zealand, Christchurch
University of Otago, Christchurch
New Zealand, Christchurch
University of Canterbury
Garraux, Gaëtan
Belgium, Liege
Université de Liège
Belgium, Liege
Centre Hospitalier Universitaire de Liege
van den Heuvel, Odile A.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Neuroscience
Khachatryan, Samson G.
Armenia, Yerevan
National Institute of Health Armenia
Armenia, Yerevan
Sleep and Movement Disorders Center
Lochner, Christine
South Africa, Stellenbosch
Stellenbosch University
Melzer, Tracy R.
New Zealand, Christchurch
New Zealand Brain Research Institute
New Zealand, Christchurch
University of Otago, Christchurch
New Zealand, Christchurch
University of Canterbury
Piras, Fabrizio
Italy, Rome
Irccs Fondazione Santa Lucia
Pitcher, Toni L.
New Zealand, Christchurch
New Zealand Brain Research Institute
New Zealand, Christchurch
University of Otago, Christchurch
Roos, Annerine
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Schmidt, Reinhold T.
Austria, Graz
Medizinische Universität Graz
Stein, Dan J.
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Tavadyan, Zaruhi D.
Armenia, Yerevan
National Institute of Health Armenia
Armenia, Yerevan
Sleep and Movement Disorders Center
Vecchio, Daniela
Italy, Rome
Irccs Fondazione Santa Lucia
Vriend, Chris
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Neuroscience
Yasuda, Clarissa Lin
Brazil, Campinas
Universidade Estadual de Campinas
Jahanshad, Neda
United States, Los Angeles
University of Southern California
Thompson, Paul M.
United States, Los Angeles
University of Southern California
Van Der Werf, Ysbrand D.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Neuroscience
Statistics
Authors: 23
Affiliations: 33
Identifiers
Doi:
10.1002/mds.29611
ISSN:
08853185
Study Design
Randomised Control Trial
Cross Sectional Study