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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long-term outcome of adalimumab therapy for ulcerative colitis with intolerance or lost response to infliximab: A single-centre experience
Alimentary Pharmacology and Therapeutics, Volume 28, No. 8, Year 2008
Notification
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Description
Background: Adalimumab may be effective in inducing remission in patients with mild-to-moderate ulcerative colitis who had secondary failure to infliximab. Aim: To evaluate long-term efficacy and safety of adalimumab in patients with ulcerative colitis who previously responded to infliximab, and then lost response or became intolerant. Methods: We report our single-centre experience in 13 patients. The patients received a loading dose of 160 mg of adalimumab subcutaneously in week 0, followed by 80 mg at week 2 and then 40 mg every other week starting at week 4. The primary efficacy measure was the proportion of patients on adalimumab therapy during the study. Results: Median duration of follow-up was 42 weeks (range, 10-100). The mean number of adalimumab infusions was 21 (range, 5-50). The probability of maintaining adalimumab was 92.3%, 84.6%, 60.6% and 32.5% at 1, 3, 6 and 23 months respectively. Six of 13 patients (46.2%) underwent colectomy during the study. No serious toxicities occurred in the study. Conclusion: Adalimumab is well-tolerated and may be effective in maintaining clinical remission in a subgroup of patients with ulcerative colitis and lost response or intolerance to infliximab, potentially avoiding colectomy in about half of the patients. © 2008 The Authors.
Authors & Co-Authors
Oussalah, Abderrahim
France, Nancy
Chu de Nancy
Algeria, Algiers
Université D’alger 1
Laclotte, C.
France, Nancy
Chu de Nancy
Chevaux, Jean Baptiste
France, Nancy
Chu de Nancy
Bensenane, Mouni
France, Nancy
Chu de Nancy
Algeria, Algiers
Université D’alger 1
Babouri, Abdenour
France, Nancy
Chu de Nancy
Algeria, Algiers
Université D’alger 1
Serre, A. A.
France, Nancy
Chu de Nancy
Boucekkine, Tadjeddine E.
Algeria, Algiers
Université D’alger 1
Roblin, Xavier
France, Saint-etienne
Centre Hospitalier Universitaire de Saint Etienne
Bigard, Marc André
France, Nancy
Chu de Nancy
Peyrin-Biroulet, Laurent
France, Nancy
Chu de Nancy
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Statistics
Citations: 96
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-2036.2008.03811.x
ISSN:
02692813
e-ISSN:
13652036
Study Design
Cohort Study