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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Vibrio cholerae O1 from Accra, Ghana carrying a class 2 integron and the SXT element
Journal of Antimicrobial Chemotherapy, Volume 62, No. 5, Year 2008
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Description
Objectives: Vibrio cholerae O1 from a 2006 outbreak in Accra were commonly resistant to multiple antimicrobials and, in particular, to trimethoprim/sulfamethoxazole, drugs commonly used in the treatment of cholera. We sought to determine the genetic basis for trimethoprim/ sulfamethoxazole resistance in outbreak isolates. Methods: Twenty-seven isolates from the outbreak were screened by PCR and sequencing for class 1 and 2 integrons and for the SXT element. Results: Twenty-one of the 27 isolates examined, all from the Accra metropolitan area, carried both SXT, an integrated chromosomal element, and a class 2 integron bearing dfrA1, sat and aadA1 cassettes. All these isolates had identical random amplification of polymorphic DNA profiles and two of them also carried a class 1 integron. Conclusions: Most strains characterized carried multiple elements conferring resistance to trimethoprim. This suggests that trimethoprim/ sulfamethoxazole should not be used empirically in cholera treatment. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Authors & Co-Authors
Opintan, Japheth
Ghana, Accra
University of Ghana
Newman, Mercy Jemima
Ghana, Accra
University of Ghana
Nsiah-Poodoh, Owusu Agyemang
Ghana, Accra
University of Ghana
Okeke, Iruka N.
United States, Haverford
Haverford College
Statistics
Citations: 56
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1093/jac/dkn334
ISSN:
03057453
e-ISSN:
14602091
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
Ghana